4H31
Crystal structure of anabolic ornithine carbamoyltransferase from Vibrio vulnificus in complex with carbamoyl phosphate and L-norvaline
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0006591 | biological_process | ornithine metabolic process |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| A | 0019240 | biological_process | citrulline biosynthetic process |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0006591 | biological_process | ornithine metabolic process |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| B | 0019240 | biological_process | citrulline biosynthetic process |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0004585 | molecular_function | ornithine carbamoyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0006591 | biological_process | ornithine metabolic process |
| C | 0016597 | molecular_function | amino acid binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
| C | 0019240 | biological_process | citrulline biosynthetic process |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA A 401 |
| Chain | Residue |
| A | ASN168 |
| A | ASN169 |
| A | ASP233 |
| A | SER237 |
| A | MET238 |
| A | LEU276 |
| A | CP402 |
| A | HOH514 |
| B | HOH503 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP A 402 |
| Chain | Residue |
| A | SER57 |
| A | THR58 |
| A | ARG59 |
| A | THR60 |
| A | ARG108 |
| A | HIS135 |
| A | GLN138 |
| A | CYS275 |
| A | LEU276 |
| A | ARG320 |
| A | NVA401 |
| B | GLN84 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PE5 A 403 |
| Chain | Residue |
| A | GLU307 |
| A | HOH676 |
| B | ALA120 |
| B | PHE121 |
| B | ARG186 |
| B | THR215 |
| B | GLU222 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 404 |
| Chain | Residue |
| A | GLU218 |
| A | ASN219 |
| A | VAL220 |
| A | HOH573 |
| A | HOH590 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 405 |
| Chain | Residue |
| A | ASP132 |
| A | MET238 |
| A | GLY239 |
| A | GLU240 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 406 |
| Chain | Residue |
| A | LYS263 |
| A | ASN267 |
| A | PRO268 |
| A | HIS310 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 407 |
| Chain | Residue |
| A | LEU13 |
| A | PHE134 |
| A | SER173 |
| A | HOH505 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 408 |
| Chain | Residue |
| A | THR215 |
| A | GLU222 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 409 |
| Chain | Residue |
| A | GLU116 |
| A | ASN260 |
| A | GLN264 |
| A | HOH575 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 410 |
| Chain | Residue |
| A | LYS253 |
| A | GLN256 |
| A | ASN258 |
| A | HOH542 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 411 |
| Chain | Residue |
| A | ASN258 |
| A | MET259 |
| A | THR302 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 412 |
| Chain | Residue |
| A | ARG96 |
| A | GLN225 |
| A | HOH617 |
| C | PHE306 |
| C | GLU307 |
| C | SER311 |
| C | PHE314 |
| C | HOH612 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 413 |
| Chain | Residue |
| A | ASP30 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA B 401 |
| Chain | Residue |
| B | ASN168 |
| B | ASN169 |
| B | ASP233 |
| B | SER237 |
| B | MET238 |
| B | LEU276 |
| B | CP402 |
| B | HOH515 |
| C | HOH531 |
| site_id | BC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP B 402 |
| Chain | Residue |
| B | SER57 |
| B | THR58 |
| B | ARG59 |
| B | THR60 |
| B | ARG108 |
| B | HIS135 |
| B | GLN138 |
| B | CYS275 |
| B | LEU276 |
| B | ARG320 |
| B | NVA401 |
| C | GLN84 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 403 |
| Chain | Residue |
| B | ALA205 |
| B | GLN209 |
| B | LYS253 |
| B | PHE294 |
| B | HOH637 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| Chain | Residue |
| B | LEU13 |
| B | PHE134 |
| B | SER173 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 405 |
| Chain | Residue |
| B | LEU262 |
| B | ASN267 |
| B | HIS310 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 406 |
| Chain | Residue |
| B | ASN258 |
| B | MET259 |
| B | THR302 |
| B | GLU304 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 407 |
| Chain | Residue |
| A | GLU283 |
| A | THR285 |
| B | GLY86 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 408 |
| Chain | Residue |
| B | ALA156 |
| B | ASP157 |
| B | ILE158 |
| B | GLY182 |
| B | GLY211 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 409 |
| Chain | Residue |
| B | ALA29 |
| B | LYS32 |
| B | GLU148 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PE5 B 410 |
| Chain | Residue |
| B | ASP132 |
| B | ARG167 |
| B | MET238 |
| B | GLY239 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 411 |
| Chain | Residue |
| B | SER17 |
| B | THR18 |
| B | LYS180 |
| B | LYS253 |
| site_id | CC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NVA C 401 |
| Chain | Residue |
| A | HOH540 |
| C | ASN168 |
| C | ASN169 |
| C | ASP233 |
| C | SER237 |
| C | MET238 |
| C | LEU276 |
| C | CP403 |
| C | HOH511 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 402 |
| Chain | Residue |
| C | LEU13 |
| C | SER173 |
| site_id | CC9 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CP C 403 |
| Chain | Residue |
| A | GLN84 |
| C | SER57 |
| C | THR58 |
| C | ARG59 |
| C | THR60 |
| C | ARG108 |
| C | HIS135 |
| C | GLN138 |
| C | CYS275 |
| C | LEU276 |
| C | ARG320 |
| C | NVA401 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PE5 C 404 |
| Chain | Residue |
| C | ASP132 |
| C | ARG167 |
| C | MET238 |
| C | HOH526 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C 405 |
| Chain | Residue |
| C | THR215 |
| C | GLU222 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG C 406 |
| Chain | Residue |
| C | LEU262 |
| C | ASN267 |
| C | HIS310 |
| site_id | DC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG C 407 |
| Chain | Residue |
| A | GLN264 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 408 |
| Chain | Residue |
| C | ASN258 |
| C | MET259 |
| C | THR302 |
| C | GLU304 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG C 409 |
| Chain | Residue |
| C | SER237 |
| C | MET238 |
| C | GLY239 |
| C | GLU240 |
| C | HOH514 |
| C | HOH546 |
| C | HOH591 |
Functional Information from PROSITE/UniProt
| site_id | PS00097 |
| Number of Residues | 8 |
| Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FeKaSTRT |
| Chain | Residue | Details |
| A | PHE53-THR60 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|Ref.3, ECO:0000269|Ref.4, ECO:0007744|PDB:4H31, ECO:0007744|PDB:4JFR, ECO:0007744|PDB:4JHX, ECO:0007744|PDB:4JQO |
| Chain | Residue | Details |
| A | CYS275 | |
| B | SER57 | |
| B | ARG108 | |
| B | HIS135 | |
| B | CYS275 | |
| C | SER57 | |
| C | ARG108 | |
| C | HIS135 | |
| C | CYS275 | |
| A | ARG108 | |
| A | HIS135 | |
| A | SER57 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|Ref.3, ECO:0000269|Ref.4, ECO:0007744|PDB:4H31, ECO:0007744|PDB:4JQO |
| Chain | Residue | Details |
| A | GLN84 | |
| B | GLN84 | |
| C | GLN84 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|Ref.3, ECO:0000269|Ref.4, ECO:0007744|PDB:4H31, ECO:0007744|PDB:4JHX, ECO:0007744|PDB:4JQO |
| Chain | Residue | Details |
| A | ASN169 | |
| A | ASP233 | |
| B | SER237 | |
| B | ARG320 | |
| C | ASN169 | |
| C | ASP233 | |
| C | SER237 | |
| C | ARG320 | |
| A | SER237 | |
| A | ARG320 | |
| B | ASN169 | |
| B | ASP233 |
