Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 301 |
| Chain | Residue |
| A | HIS226 |
| A | HIS230 |
| A | HIS236 |
| B | 0Y3306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 302 |
| Chain | Residue |
| A | HIS175 |
| A | ASP177 |
| A | HIS190 |
| A | HIS203 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 303 |
| Chain | Residue |
| A | GLY197 |
| A | GLN199 |
| A | ASP201 |
| A | ASP165 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 304 |
| Chain | Residue |
| A | ASP182 |
| A | GLY183 |
| A | ASP185 |
| A | LEU187 |
| A | ASP205 |
| A | GLU208 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 305 |
| Chain | Residue |
| A | LYS258 |
| B | ALA146 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 306 |
| Chain | Residue |
| A | GLU241 |
| A | HOH425 |
| B | PEG308 |
| B | HOH460 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 307 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 308 |
| Chain | Residue |
| A | TYR179 |
| A | PEG307 |
| A | HOH420 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 309 |
| Chain | Residue |
| A | ALA173 |
| A | GLU174 |
| A | PHE181 |
| A | ACT312 |
| A | BCN314 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 310 |
| Chain | Residue |
| A | ASN127 |
| A | VAL172 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 311 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 312 |
| site_id | BC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 313 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE BCN A 314 |
| Chain | Residue |
| A | ASP182 |
| A | PEG309 |
| B | ARG249 |
| B | GLU252 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE BCN A 315 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 301 |
| Chain | Residue |
| B | HIS226 |
| B | HIS230 |
| B | HIS236 |
| B | 0Y3306 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 302 |
| Chain | Residue |
| B | HIS175 |
| B | ASP177 |
| B | HIS190 |
| B | HIS203 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 303 |
| Chain | Residue |
| B | ALA164 |
| B | ASP165 |
| B | GLY197 |
| B | GLN199 |
| B | ASP201 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 304 |
| Chain | Residue |
| B | ASP182 |
| B | GLY183 |
| B | ASP185 |
| B | LEU187 |
| B | ASP205 |
| B | GLU208 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 305 |
| Chain | Residue |
| B | SER129 |
| B | ASP131 |
| B | ASP206 |
| B | GLU208 |
| B | TRP210 |
| site_id | CC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE 0Y3 B 306 |
| Chain | Residue |
| B | HOH459 |
| A | LEU187 |
| A | LEU188 |
| A | ALA189 |
| A | LEU222 |
| A | HIS226 |
| A | GLU227 |
| A | HIS230 |
| A | ASP235 |
| A | HIS236 |
| A | LEU243 |
| A | TYR245 |
| A | PRO246 |
| A | TYR248 |
| A | ZN301 |
| B | GLY106 |
| B | PHE107 |
| B | LEU188 |
| B | ALA189 |
| B | LEU222 |
| B | VAL223 |
| B | HIS226 |
| B | GLU227 |
| B | HIS230 |
| B | ASP235 |
| B | HIS236 |
| B | LEU243 |
| B | TYR245 |
| B | PRO246 |
| B | MET247 |
| B | TYR248 |
| B | ZN301 |
| B | HOH437 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 307 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 308 |
| Chain | Residue |
| A | PEG306 |
| B | PRO180 |
| B | PEG307 |
| B | PEG309 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 309 |
| Chain | Residue |
| B | GLY178 |
| B | TYR179 |
| B | PEG308 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT B 310 |
| Chain | Residue |
| B | PHE250 |
| B | THR251 |
| B | GLU252 |
| B | HOH458 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BCN B 311 |
| Chain | Residue |
| B | ALA173 |
| B | GLU174 |
| B | PRO180 |
| B | PHE181 |
| B | HOH449 |
| B | HOH457 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAL |
| Chain | Residue | Details |
| A | VAL223-LEU232 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12051944","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12077439","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
