4H2A

Crystal structure of wild type protective antigen to 1.62 A (pH 7.5)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0042802	molecular_function	identical protein binding
A	0044164	cellular_component	host cell cytosol
A	0044174	cellular_component	host cell endosome
A	0044175	cellular_component	host cell endosome membrane
A	0044533	biological_process	obsolete positive regulation of apoptotic process in another organism
A	0046872	molecular_function	metal ion binding
A	0051260	biological_process	protein homooligomerization
A	0090729	molecular_function	toxin activity
A	0141070	biological_process	symbiont-mediated suppression of host MAPK cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 801

Chain	Residue
A	SER475
A	ASN476
A	GLU479
A	HOH941
A	HOH1410

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 802

Chain	Residue
A	TYR456
A	GLN485
A	HOH1000
A	PRO260
A	ASN326
A	ASN328
A	GLN454

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 803

Chain	Residue
A	THR393
A	LEU421
A	THR430
A	HOH956

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 804

Chain	Residue
A	ILE656
A	ASP677
A	PHE678
A	LYS680
A	TYR681

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 805

Chain	Residue
A	ASP179
A	ASP181
A	GLU188
A	SER222
A	LYS225
A	ASP235

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 806

Chain	Residue
A	ASP177
A	ASP179
A	ASP181
A	ILE183
A	GLU188
A	HOH908

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Domain: {"description":"PA14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01164","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	38
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Region: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	107
Details	Region: {"description":"Domain 3, heptamerization","evidences":[{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9039918","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3J9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15243628","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15326297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32047164","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ACC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T6B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3KWV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6UZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Site: {"description":"Cleavage; by FURIN","evidences":[{"source":"PubMed","id":"11207581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1438214","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1644824","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	Site: {"description":"Alpha-clamp","evidences":[{"source":"PubMed","id":"21037566","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Site: {"description":"Phi-clamp","evidences":[{"source":"PubMed","id":"16051798","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25778700","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Site: {"description":"Essential for binding to cell receptor","evidences":[{"source":"PubMed","id":"12771151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---