4H10

Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic Helix-Loop-Helix domains with E-box DNA

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Functional Information from GO Data

ChainGOidnamespacecontents
A0033391cellular_componentchromatoid body
A0043231cellular_componentintracellular membrane-bounded organelle
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0016605cellular_componentPML body
A0005667cellular_componenttranscription factor complex
A0017162molecular_functionaryl hydrocarbon receptor binding
A0043425molecular_functionbHLH transcription factor binding
A0003677molecular_functionDNA binding
A0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0070888molecular_functionE-box binding
A0051879molecular_functionHsp90 protein binding
A0046982molecular_functionprotein heterodimerization activity
A0070491molecular_functionrepressing transcription factor binding
A0000980molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding
A0043565molecular_functionsequence-specific DNA binding
A0000976molecular_functiontranscription regulatory region sequence-specific DNA binding
A0032922biological_processcircadian regulation of gene expression
A0007623biological_processcircadian rhythm
A0060137biological_processmaternal process involved in parturition
A0120163biological_processnegative regulation of cold-induced thermogenesis
A0045599biological_processnegative regulation of fat cell differentiation
A2000323biological_processnegative regulation of glucocorticoid receptor signaling pathway
A0032007biological_processnegative regulation of TOR signaling
A0045892biological_processnegative regulation of transcription, DNA-templated
A0090403biological_processoxidative stress-induced premature senescence
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0042753biological_processpositive regulation of circadian rhythm
A1901985biological_processpositive regulation of protein acetylation
A2001016biological_processpositive regulation of skeletal muscle cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045893biological_processpositive regulation of transcription, DNA-templated
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051726biological_processregulation of cell cycle
A2000772biological_processregulation of cellular senescence
A0042634biological_processregulation of hair cycle
A0050796biological_processregulation of insulin secretion
A0050767biological_processregulation of neurogenesis
A0042176biological_processregulation of protein catabolic process
A0006355biological_processregulation of transcription, DNA-templated
A2000074biological_processregulation of type B pancreatic cell development
A0051775biological_processresponse to redox state
A0007283biological_processspermatogenesis
B0033391cellular_componentchromatoid body
B0005694cellular_componentchromosome
B0005829cellular_componentcytosol
B0043231cellular_componentintracellular membrane-bounded organelle
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0005667cellular_componenttranscription factor complex
B0031490molecular_functionchromatin DNA binding
B0003677molecular_functionDNA binding
B0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
B0003700molecular_functionDNA-binding transcription factor activity
B0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
B0070888molecular_functionE-box binding
B0004402molecular_functionhistone acetyltransferase activity
B0046983molecular_functionprotein dimerization activity
B0000980molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding
B0000978molecular_functionRNA polymerase II proximal promoter sequence-specific DNA binding
B0043565molecular_functionsequence-specific DNA binding
B0071479biological_processcellular response to ionizing radiation
B0032922biological_processcircadian regulation of gene expression
B0007623biological_processcircadian rhythm
B0000077biological_processDNA damage checkpoint
B2000323biological_processnegative regulation of glucocorticoid receptor signaling pathway
B0045892biological_processnegative regulation of transcription, DNA-templated
B0009648biological_processphotoperiodism
B0050729biological_processpositive regulation of inflammatory response
B0051092biological_processpositive regulation of NF-kappaB transcription factor activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0045893biological_processpositive regulation of transcription, DNA-templated
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0006473biological_processprotein acetylation
B0042634biological_processregulation of hair cycle
B0050796biological_processregulation of insulin secretion
B0006357biological_processregulation of transcription by RNA polymerase II
B0006355biological_processregulation of transcription, DNA-templated
B2000074biological_processregulation of type B pancreatic cell development
B0051775biological_processresponse to redox state
B0007165biological_processsignal transduction
B0007283biological_processspermatogenesis
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Functional Information from PDB Data

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

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Functional Information from PROSITE/UniProt

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Functional Information from SwissProt/UniProt

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Catalytic Information from CSA

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