4H0U

Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004799	molecular_function	thymidylate synthase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
B	0004799	molecular_function	thymidylate synthase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006231	biological_process	dTMP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0008168	molecular_function	methyltransferase activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0032259	biological_process	methylation
C	0004799	molecular_function	thymidylate synthase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006231	biological_process	dTMP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0008168	molecular_function	methyltransferase activity
C	0009165	biological_process	nucleotide biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016741	molecular_function	transferase activity, transferring one-carbon groups
C	0032259	biological_process	methylation
D	0004799	molecular_function	thymidylate synthase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006231	biological_process	dTMP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0008168	molecular_function	methyltransferase activity
D	0009165	biological_process	nucleotide biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016741	molecular_function	transferase activity, transferring one-carbon groups
D	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UMP A 301

Chain	Residue
A	CYS149
A	TYR212
B	ARG129
B	ARG130
A	HIS150
A	GLN168
A	ARG169
A	SER170
A	ASP172
A	GLY176
A	ASN180
A	HIS210

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE UMP B 301

Chain	Residue
A	ARG129
A	ARG130
B	CYS149
B	HIS150
B	GLN168
B	ARG169
B	SER170
B	ASP172
B	GLY176
B	ASN180
B	HIS210
B	TYR212
B	HOH407

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE UMP C 301

Chain	Residue
C	CYS149
C	HIS150
C	GLN168
C	ARG169
C	SER170
C	ASP172
C	ASN180
C	HIS210
C	TYR212
D	ARG129
D	ARG130

---

site_id	AC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE UMP D 301

Chain	Residue
C	ARG129
C	ARG130
D	CYS149
D	HIS150
D	GLN168
D	ARG169
D	SER170
D	ASP172
D	GLY176
D	ASN180
D	HIS210
D	TYR212

---

Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrnIvsaWNvselenma.....LpPCHllfQLyV

Chain	Residue	Details
A	ARG129-VAL157

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---