4H0U
Crystal structure of thymidylate synthase from Corynebacterium glutamicum in complex with dUMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| C | 0004799 | molecular_function | thymidylate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006231 | biological_process | dTMP biosynthetic process |
| C | 0006235 | biological_process | dTTP biosynthetic process |
| C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| D | 0004799 | molecular_function | thymidylate synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006231 | biological_process | dTMP biosynthetic process |
| D | 0006235 | biological_process | dTTP biosynthetic process |
| D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP A 301 |
| Chain | Residue |
| A | CYS149 |
| A | TYR212 |
| B | ARG129 |
| B | ARG130 |
| A | HIS150 |
| A | GLN168 |
| A | ARG169 |
| A | SER170 |
| A | ASP172 |
| A | GLY176 |
| A | ASN180 |
| A | HIS210 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UMP B 301 |
| Chain | Residue |
| A | ARG129 |
| A | ARG130 |
| B | CYS149 |
| B | HIS150 |
| B | GLN168 |
| B | ARG169 |
| B | SER170 |
| B | ASP172 |
| B | GLY176 |
| B | ASN180 |
| B | HIS210 |
| B | TYR212 |
| B | HOH407 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE UMP C 301 |
| Chain | Residue |
| C | CYS149 |
| C | HIS150 |
| C | GLN168 |
| C | ARG169 |
| C | SER170 |
| C | ASP172 |
| C | ASN180 |
| C | HIS210 |
| C | TYR212 |
| D | ARG129 |
| D | ARG130 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE UMP D 301 |
| Chain | Residue |
| C | ARG129 |
| C | ARG130 |
| D | CYS149 |
| D | HIS150 |
| D | GLN168 |
| D | ARG169 |
| D | SER170 |
| D | ASP172 |
| D | GLY176 |
| D | ASN180 |
| D | HIS210 |
| D | TYR212 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrnIvsaWNvselenma.....LpPCHllfQLyV |
| Chain | Residue | Details |
| A | ARG129-VAL157 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"HAMAP-Rule","id":"MF_00008","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
