4H0N

Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008033	biological_process	tRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0032259	biological_process	methylation
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0008033	biological_process	tRNA processing
B	0008168	molecular_function	methyltransferase activity
B	0032259	biological_process	methylation
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0008033	biological_process	tRNA processing
C	0008168	molecular_function	methyltransferase activity
C	0032259	biological_process	methylation
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0008033	biological_process	tRNA processing
D	0008168	molecular_function	methyltransferase activity
D	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 401

Chain	Residue
A	TYR9
A	ASN55
A	ILE56
A	SER75
A	PRO77
A	SER97
A	ASN316
A	SER317
A	VAL318
A	SER10
A	GLY11
A	ILE12
A	GLY14
A	ASP33
A	ILE34
A	ASN35
A	ARG54

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	GLY103
A	ASP106
B	ASP133
B	GLU137

---

site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH B 401

Chain	Residue
B	TYR9
B	SER10
B	GLY11
B	ILE12
B	GLY13
B	GLY14
B	ASP33
B	ILE34
B	ASN35
B	ASN55
B	ILE56
B	SER75
B	PRO77
B	GLN79
B	SER97
B	ASN316
B	SER317

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 402

Chain	Residue
A	ASP133
A	GLU137
B	GLY103
B	ASP106
B	GLN107

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SAH C 401

Chain	Residue
C	TYR9
C	SER10
C	GLY11
C	ILE12
C	ASP33
C	ILE34
C	ARG54
C	ASN55
C	ILE56
C	SER75
C	PRO77
C	SER97
C	ASN316
C	SER317
C	VAL318

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA C 402

Chain	Residue
C	GLY103
C	ASP106

---

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH D 401

Chain	Residue
D	TYR9
D	SER10
D	GLY11
D	ILE12
D	GLY14
D	ASP33
D	ILE34
D	ASN35
D	ASN55
D	ILE56
D	SER75
D	PRO77
D	GLN79
D	SER97
D	ASN316
D	SER317
D	VAL318

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CA D 402

Chain	Residue
D	GLY103
D	ASP106

---

Functional Information from PROSITE/UniProt

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RllGNSVnVkViseLlkiL

Chain	Residue	Details
A	ARG312-LEU330

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01016

Chain	Residue	Details
A	CYS78
B	CYS78
C	CYS78
D	CYS78

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:23103599, ECO:0007744|PDB:4H0N

Chain	Residue	Details
A	ILE12
C	ASP33
C	ASN55
C	ASN316
D	ILE12
D	ASP33
D	ASN55
D	ASN316
A	ASP33
A	ASN55
A	ASN316
B	ILE12
B	ASP33
B	ASN55
B	ASN316
C	ILE12

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|Ref.2, ECO:0007744|PDB:4H0N

Chain	Residue	Details
A	SER75
D	SER75
D	GLN79
D	SER97
A	GLN79
A	SER97
B	SER75
B	GLN79
B	SER97
C	SER75
C	GLN79
C	SER97

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