4H0N
Crystal structure of Spodoptera frugiperda DNMT2 E260A/E261A/K263A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008033 | biological_process | tRNA processing |
| C | 0008168 | molecular_function | methyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0032259 | biological_process | methylation |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008033 | biological_process | tRNA processing |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH A 401 |
| Chain | Residue |
| A | TYR9 |
| A | ASN55 |
| A | ILE56 |
| A | SER75 |
| A | PRO77 |
| A | SER97 |
| A | ASN316 |
| A | SER317 |
| A | VAL318 |
| A | SER10 |
| A | GLY11 |
| A | ILE12 |
| A | GLY14 |
| A | ASP33 |
| A | ILE34 |
| A | ASN35 |
| A | ARG54 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 402 |
| Chain | Residue |
| A | GLY103 |
| A | ASP106 |
| B | ASP133 |
| B | GLU137 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH B 401 |
| Chain | Residue |
| B | TYR9 |
| B | SER10 |
| B | GLY11 |
| B | ILE12 |
| B | GLY13 |
| B | GLY14 |
| B | ASP33 |
| B | ILE34 |
| B | ASN35 |
| B | ASN55 |
| B | ILE56 |
| B | SER75 |
| B | PRO77 |
| B | GLN79 |
| B | SER97 |
| B | ASN316 |
| B | SER317 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 402 |
| Chain | Residue |
| A | ASP133 |
| A | GLU137 |
| B | GLY103 |
| B | ASP106 |
| B | GLN107 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SAH C 401 |
| Chain | Residue |
| C | TYR9 |
| C | SER10 |
| C | GLY11 |
| C | ILE12 |
| C | ASP33 |
| C | ILE34 |
| C | ARG54 |
| C | ASN55 |
| C | ILE56 |
| C | SER75 |
| C | PRO77 |
| C | SER97 |
| C | ASN316 |
| C | SER317 |
| C | VAL318 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 402 |
| Chain | Residue |
| C | GLY103 |
| C | ASP106 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH D 401 |
| Chain | Residue |
| D | TYR9 |
| D | SER10 |
| D | GLY11 |
| D | ILE12 |
| D | GLY14 |
| D | ASP33 |
| D | ILE34 |
| D | ASN35 |
| D | ASN55 |
| D | ILE56 |
| D | SER75 |
| D | PRO77 |
| D | GLN79 |
| D | SER97 |
| D | ASN316 |
| D | SER317 |
| D | VAL318 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA D 402 |
| Chain | Residue |
| D | GLY103 |
| D | ASP106 |
Functional Information from PROSITE/UniProt
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RllGNSVnVkViseLlkiL |
| Chain | Residue | Details |
| A | ARG312-LEU330 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1316 |
| Details | Domain: {"description":"SAM-dependent MTase C5-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23103599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4H0N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2016","submissionDatabase":"EMBL/GenBank/DDBJ databases","authors":["Bretaudeau A."]}},{"source":"PDB","id":"4H0N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
