4GZ5
Crystal structure of human O-GlcNAc Transferase with UDP-GlcNAc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0006493 | biological_process | protein O-linked glycosylation |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0006493 | biological_process | protein O-linked glycosylation |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0006493 | biological_process | protein O-linked glycosylation |
| D | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE UD1 A 1501 |
| Chain | Residue |
| A | HIS498 |
| A | GLN839 |
| A | TYR841 |
| A | LYS842 |
| A | LEU866 |
| A | VAL895 |
| A | ALA896 |
| A | LYS898 |
| A | HIS901 |
| A | ARG904 |
| A | CYS917 |
| A | MET501 |
| A | HIS920 |
| A | THR921 |
| A | THR922 |
| A | ASP925 |
| A | THR560 |
| A | HIS562 |
| A | LEU563 |
| A | LEU653 |
| A | GLY654 |
| A | PRO656 |
| A | PHE694 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1502 |
| Chain | Residue |
| A | ASN321 |
| A | ASN325 |
| A | ASN356 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1503 |
| Chain | Residue |
| A | ARG867 |
| A | PHE892 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1504 |
| Chain | Residue |
| A | ASN962 |
| A | ARG963 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1505 |
| Chain | Residue |
| A | LYS366 |
| A | LEU367 |
| A | GLN368 |
| A | GLU369 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE UD1 B 1501 |
| Chain | Residue |
| B | HIS498 |
| B | MET501 |
| B | THR560 |
| B | LEU563 |
| B | LEU653 |
| B | GLY654 |
| B | PRO656 |
| B | PHE694 |
| B | GLN839 |
| B | TYR841 |
| B | LYS842 |
| B | LEU866 |
| B | VAL895 |
| B | ALA896 |
| B | LYS898 |
| B | HIS901 |
| B | ARG904 |
| B | CYS917 |
| B | HIS920 |
| B | THR921 |
| B | THR922 |
| B | ASP925 |
| B | HOH1604 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1502 |
| Chain | Residue |
| B | ASN321 |
| B | ASN325 |
| B | ALA352 |
| B | ASN356 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1503 |
| Chain | Residue |
| B | ARG867 |
| B | PRO894 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1504 |
| Chain | Residue |
| B | MET936 |
| B | ASN962 |
| B | ARG963 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1505 |
| Chain | Residue |
| B | LYS366 |
| B | LEU367 |
| B | GLN368 |
| B | GLU369 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE UD1 C 1501 |
| Chain | Residue |
| C | HIS498 |
| C | MET501 |
| C | PRO559 |
| C | THR560 |
| C | LEU653 |
| C | GLY654 |
| C | PRO656 |
| C | GLN839 |
| C | TYR841 |
| C | LYS842 |
| C | LEU866 |
| C | VAL895 |
| C | ALA896 |
| C | LYS898 |
| C | HIS901 |
| C | ARG904 |
| C | CYS917 |
| C | HIS920 |
| C | THR921 |
| C | THR922 |
| C | ASP925 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1502 |
| Chain | Residue |
| C | ASN321 |
| C | ASN325 |
| C | ALA352 |
| C | ASN356 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1503 |
| Chain | Residue |
| C | ARG867 |
| C | PHE892 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1504 |
| Chain | Residue |
| C | ARG963 |
| C | MET936 |
| C | ASN962 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1505 |
| Chain | Residue |
| C | LYS366 |
| C | LEU367 |
| C | GLN368 |
| C | GLU369 |
| site_id | BC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE UD1 D 1501 |
| Chain | Residue |
| D | CYS313 |
| D | HIS498 |
| D | MET501 |
| D | PRO559 |
| D | THR560 |
| D | LEU653 |
| D | GLY654 |
| D | PRO656 |
| D | PHE694 |
| D | GLN839 |
| D | TYR841 |
| D | LYS842 |
| D | LEU866 |
| D | VAL895 |
| D | ALA896 |
| D | LYS898 |
| D | HIS901 |
| D | ARG904 |
| D | CYS917 |
| D | HIS920 |
| D | THR921 |
| D | THR922 |
| D | ASP925 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1502 |
| Chain | Residue |
| D | ASN321 |
| D | ASN356 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1503 |
| Chain | Residue |
| D | ARG867 |
| D | PHE892 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1504 |
| Chain | Residue |
| D | MET936 |
| D | ASN962 |
| D | ARG963 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1505 |
| Chain | Residue |
| D | LYS366 |
| D | LEU367 |
| D | GLN368 |
| D | GLU369 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539 |
| Chain | Residue | Details |
| A | HIS498 | |
| B | HIS498 | |
| C | HIS498 | |
| D | HIS498 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW |
| Chain | Residue | Details |
| A | GLN839 | |
| B | HIS901 | |
| B | HIS920 | |
| B | ASP925 | |
| C | GLN839 | |
| C | LYS842 | |
| C | ALA896 | |
| C | HIS901 | |
| C | HIS920 | |
| C | ASP925 | |
| D | GLN839 | |
| A | LYS842 | |
| D | LYS842 | |
| D | ALA896 | |
| D | HIS901 | |
| D | HIS920 | |
| D | ASP925 | |
| A | ALA896 | |
| A | HIS901 | |
| A | HIS920 | |
| A | ASP925 | |
| B | GLN839 | |
| B | LYS842 | |
| B | ALA896 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| A | THR444 | |
| B | THR444 | |
| C | THR444 | |
| D | THR444 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558 |
| Chain | Residue | Details |
| A | TYR979 | |
| B | TYR979 | |
| C | TYR979 | |
| D | TYR979 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473 |
| Chain | Residue | Details |
| A | SER389 | |
| B | SER389 | |
| C | SER389 | |
| D | SER389 |
