4GWP

Structure of the Mediator Head Module from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001097	molecular_function	TFIIH-class transcription factor complex binding
A	0003712	molecular_function	transcription coregulator activity
A	0003713	molecular_function	transcription coactivator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0006351	biological_process	DNA-templated transcription
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016592	cellular_component	mediator complex
A	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0051123	biological_process	RNA polymerase II preinitiation complex assembly
A	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
A	0070847	cellular_component	core mediator complex
B	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
B	0001139	molecular_function	RNA polymerase II complex recruiting activity
B	0003712	molecular_function	transcription coregulator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0016592	cellular_component	mediator complex
B	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
B	0034605	biological_process	cellular response to heat
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0051123	biological_process	RNA polymerase II preinitiation complex assembly
B	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
B	0070847	cellular_component	core mediator complex
B	0140297	molecular_function	DNA-binding transcription factor binding
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0003712	molecular_function	transcription coregulator activity
C	0003714	molecular_function	transcription corepressor activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0006351	biological_process	DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0016592	cellular_component	mediator complex
C	0017025	molecular_function	TBP-class protein binding
C	0019865	molecular_function	immunoglobulin binding
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051123	biological_process	RNA polymerase II preinitiation complex assembly
C	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
C	0070847	cellular_component	core mediator complex
D	0003674	molecular_function	molecular_function
D	0003712	molecular_function	transcription coregulator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0006351	biological_process	DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0016592	cellular_component	mediator complex
D	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0051123	biological_process	RNA polymerase II preinitiation complex assembly
D	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
D	0070847	cellular_component	core mediator complex
E	0000979	molecular_function	RNA polymerase II core promoter sequence-specific DNA binding
E	0001113	biological_process	transcription open complex formation at RNA polymerase II promoter
E	0003712	molecular_function	transcription coregulator activity
E	0003713	molecular_function	transcription coactivator activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006369	biological_process	termination of RNA polymerase II transcription
E	0016592	cellular_component	mediator complex
E	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
E	0034605	biological_process	cellular response to heat
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0051123	biological_process	RNA polymerase II preinitiation complex assembly
E	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
E	0070847	cellular_component	core mediator complex
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003712	molecular_function	transcription coregulator activity
F	0003713	molecular_function	transcription coactivator activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0006351	biological_process	DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0010688	biological_process	negative regulation of ribosomal protein gene transcription by RNA polymerase II
F	0016592	cellular_component	mediator complex
F	0019904	molecular_function	protein domain specific binding
F	0031669	biological_process	cellular response to nutrient levels
F	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
F	0032991	cellular_component	protein-containing complex
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051123	biological_process	RNA polymerase II preinitiation complex assembly
F	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
F	0070847	cellular_component	core mediator complex
G	0003712	molecular_function	transcription coregulator activity
G	0003713	molecular_function	transcription coactivator activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0006351	biological_process	DNA-templated transcription
G	0006357	biological_process	regulation of transcription by RNA polymerase II
G	0016592	cellular_component	mediator complex
G	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0051123	biological_process	RNA polymerase II preinitiation complex assembly
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0070847	cellular_component	core mediator complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	77
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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