4GVU
Lyngbyastatin 7-Porcine Pancreatic Elastase Co-crystal Structure
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006508 | biological_process | proteolysis |
| A | 0006954 | biological_process | inflammatory response |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | GLU74 |
| A | ASN76 |
| A | GLN79 |
| A | GLU84 |
| A | HOH495 |
| A | HOH626 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | SER242 |
| A | ALA243 |
| A | HOH544 |
| A | HOH630 |
| A | GLY133 |
| A | ARG151 |
| A | ARG240 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR CHAIN B OF LYNGBYASTATIN 7 |
| Chain | Residue |
| A | THR44 |
| A | HIS60 |
| A | GLU65 |
| A | LEU66 |
| A | VAL103 |
| A | LEU156 |
| A | THR182 |
| A | CYS199 |
| A | GLN200 |
| A | GLY201 |
| A | SER203 |
| A | SER222 |
| A | PHE223 |
| A | VAL224 |
| A | ARG226 |
| A | HOH419 |
| A | HOH524 |
| B | HOH105 |
| B | HOH108 |
| B | HOH109 |
| B | HOH111 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 237 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"4578945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7656008","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ELA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
