4GV5
X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0015459 | molecular_function | potassium channel regulator activity |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044562 | biological_process | venom-mediated inhibition of voltage-gated potassium channel activity |
| A | 0050832 | biological_process | defense response to fungus |
| A | 0090729 | molecular_function | toxin activity |
| A | 0099106 | molecular_function | ion channel regulator activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0015459 | molecular_function | potassium channel regulator activity |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0042742 | biological_process | defense response to bacterium |
| B | 0044562 | biological_process | venom-mediated inhibition of voltage-gated potassium channel activity |
| B | 0050832 | biological_process | defense response to fungus |
| B | 0090729 | molecular_function | toxin activity |
| B | 0099106 | molecular_function | ion channel regulator activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0015459 | molecular_function | potassium channel regulator activity |
| C | 0031640 | biological_process | killing of cells of another organism |
| C | 0042742 | biological_process | defense response to bacterium |
| C | 0044562 | biological_process | venom-mediated inhibition of voltage-gated potassium channel activity |
| C | 0050832 | biological_process | defense response to fungus |
| C | 0090729 | molecular_function | toxin activity |
| C | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SCN A 101 |
| Chain | Residue |
| A | ILE17 |
| A | HOH204 |
| C | TYR1 |
| C | TRP34 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SCN A 102 |
| Chain | Residue |
| A | PRO13 |
| A | LYS14 |
| A | GLU15 |
| B | PRO21 |
| C | PRO13 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 103 |
| Chain | Residue |
| A | LYS14 |
| A | TRP32 |
| A | ARG33 |
| B | PRO21 |
| B | SER22 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 104 |
| Chain | Residue |
| A | GLN3 |
| A | TRP32 |
| A | ARG33 |
| A | HOH215 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 101 |
| Chain | Residue |
| B | LYS2 |
| B | GLN3 |
| B | TRP32 |
| B | ARG33 |
| B | HOH209 |
| B | HOH211 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 102 |
| Chain | Residue |
| B | TYR1 |
| B | HIS10 |
| B | CYS11 |
| B | HOH213 |
| C | ARG31 |
| C | TRP32 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SCN B 103 |
| Chain | Residue |
| B | PHE12 |
| B | PRO13 |
| B | ILE17 |
| B | GLY42 |
| C | GOL103 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 101 |
| Chain | Residue |
| A | PHE12 |
| A | PRO13 |
| A | LYS16 |
| C | HIS10 |
| C | CYS11 |
| C | HOH204 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SCN C 102 |
| Chain | Residue |
| C | TRP32 |
| C | ARG33 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 103 |
| Chain | Residue |
| B | PHE12 |
| B | GLY42 |
| B | SCN103 |
| C | ARG31 |
| C | TRP32 |
| C | ARG33 |
| C | TRP34 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 104 |
| Chain | Residue |
| B | LEU19 |
| B | PRO20 |
| B | PRO21 |
| C | PRO13 |
| C | LYS14 |
| C | GLU15 |
| C | LYS16 |
Functional Information from PROSITE/UniProt
| site_id | PS00459 |
| Number of Residues | 38 |
| Details | MYOTOXINS_1 Myotoxins signature. KqCHkKggHCfpKekiClppssdfgKmdCrwRwKCCKK |
| Chain | Residue | Details |
| A | LYS2-LYS39 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Motif: {"description":"Nuclear localization signal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Site: {"description":"Involved in the interaction surface toward Kv","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
