4GUN
Crystal Structure of the K184R, L185P mutant manganese superoxide dismutase from Candida albicans cytosol
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004784 | molecular_function | superoxide dismutase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006801 | biological_process | superoxide metabolic process |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004784 | molecular_function | superoxide dismutase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006801 | biological_process | superoxide metabolic process |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004784 | molecular_function | superoxide dismutase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0006801 | biological_process | superoxide metabolic process |
| C | 0019430 | biological_process | removal of superoxide radicals |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004784 | molecular_function | superoxide dismutase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0006801 | biological_process | superoxide metabolic process |
| D | 0019430 | biological_process | removal of superoxide radicals |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0004784 | molecular_function | superoxide dismutase activity |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0006801 | biological_process | superoxide metabolic process |
| E | 0019430 | biological_process | removal of superoxide radicals |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0004784 | molecular_function | superoxide dismutase activity |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0006801 | biological_process | superoxide metabolic process |
| F | 0019430 | biological_process | removal of superoxide radicals |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0004784 | molecular_function | superoxide dismutase activity |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0006801 | biological_process | superoxide metabolic process |
| G | 0019430 | biological_process | removal of superoxide radicals |
| G | 0030145 | molecular_function | manganese ion binding |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0004784 | molecular_function | superoxide dismutase activity |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0006801 | biological_process | superoxide metabolic process |
| H | 0019430 | biological_process | removal of superoxide radicals |
| H | 0030145 | molecular_function | manganese ion binding |
| H | 0046872 | molecular_function | metal ion binding |
| I | 0004784 | molecular_function | superoxide dismutase activity |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0006801 | biological_process | superoxide metabolic process |
| I | 0019430 | biological_process | removal of superoxide radicals |
| I | 0030145 | molecular_function | manganese ion binding |
| I | 0046872 | molecular_function | metal ion binding |
| J | 0004784 | molecular_function | superoxide dismutase activity |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0006801 | biological_process | superoxide metabolic process |
| J | 0019430 | biological_process | removal of superoxide radicals |
| J | 0030145 | molecular_function | manganese ion binding |
| J | 0046872 | molecular_function | metal ion binding |
| K | 0004784 | molecular_function | superoxide dismutase activity |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0006801 | biological_process | superoxide metabolic process |
| K | 0019430 | biological_process | removal of superoxide radicals |
| K | 0030145 | molecular_function | manganese ion binding |
| K | 0046872 | molecular_function | metal ion binding |
| L | 0004784 | molecular_function | superoxide dismutase activity |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0006801 | biological_process | superoxide metabolic process |
| L | 0019430 | biological_process | removal of superoxide radicals |
| L | 0030145 | molecular_function | manganese ion binding |
| L | 0046872 | molecular_function | metal ion binding |
| M | 0004784 | molecular_function | superoxide dismutase activity |
| M | 0005739 | cellular_component | mitochondrion |
| M | 0006801 | biological_process | superoxide metabolic process |
| M | 0019430 | biological_process | removal of superoxide radicals |
| M | 0030145 | molecular_function | manganese ion binding |
| M | 0046872 | molecular_function | metal ion binding |
| N | 0004784 | molecular_function | superoxide dismutase activity |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0006801 | biological_process | superoxide metabolic process |
| N | 0019430 | biological_process | removal of superoxide radicals |
| N | 0030145 | molecular_function | manganese ion binding |
| N | 0046872 | molecular_function | metal ion binding |
| O | 0004784 | molecular_function | superoxide dismutase activity |
| O | 0005739 | cellular_component | mitochondrion |
| O | 0006801 | biological_process | superoxide metabolic process |
| O | 0019430 | biological_process | removal of superoxide radicals |
| O | 0030145 | molecular_function | manganese ion binding |
| O | 0046872 | molecular_function | metal ion binding |
| P | 0004784 | molecular_function | superoxide dismutase activity |
| P | 0005739 | cellular_component | mitochondrion |
| P | 0006801 | biological_process | superoxide metabolic process |
| P | 0019430 | biological_process | removal of superoxide radicals |
| P | 0030145 | molecular_function | manganese ion binding |
| P | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 301 |
| Chain | Residue |
| A | HIS32 |
| A | HIS80 |
| A | ASP170 |
| A | HIS174 |
| A | HOH423 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | SER102 |
| A | ALA103 |
| A | SER205 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 301 |
| Chain | Residue |
| B | HIS80 |
| B | ASP170 |
| B | HIS174 |
| B | HOH403 |
| B | HIS32 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | ALA103 |
| B | SER205 |
| B | HOH406 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN C 301 |
| Chain | Residue |
| C | HIS32 |
| C | HIS80 |
| C | ASP170 |
| C | HIS174 |
| C | HOH404 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | LYS125 |
| C | VAL150 |
| C | THR151 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | SER102 |
| C | ALA103 |
| C | SER205 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN D 301 |
| Chain | Residue |
| D | HIS32 |
| D | HIS80 |
| D | ASP170 |
| D | HIS174 |
| D | HOH411 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | SER102 |
| D | ALA103 |
| D | SER205 |
| D | HOH425 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| B | ARG58 |
| D | ILE8 |
| D | SER9 |
| D | HIS77 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN E 301 |
| Chain | Residue |
| E | HIS32 |
| E | HIS80 |
| E | ASP170 |
| E | HIS174 |
| E | HOH407 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 302 |
| Chain | Residue |
| E | ALA16 |
| E | LEU17 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 303 |
| Chain | Residue |
| E | SER102 |
| E | ALA103 |
| E | SER205 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN F 301 |
| Chain | Residue |
| F | HIS32 |
| F | HIS80 |
| F | ASP170 |
| F | HIS174 |
| F | HOH417 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 302 |
| Chain | Residue |
| F | LYS125 |
| F | VAL150 |
| F | THR151 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 303 |
| Chain | Residue |
| F | SER102 |
| F | ALA103 |
| F | SER205 |
| F | HOH413 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN G 301 |
| Chain | Residue |
| G | HIS32 |
| G | HIS80 |
| G | ASP170 |
| G | HIS174 |
| G | HOH426 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 G 302 |
| Chain | Residue |
| G | ALA16 |
| G | LEU17 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 303 |
| Chain | Residue |
| G | SER102 |
| G | ALA103 |
| G | SER205 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN H 301 |
| Chain | Residue |
| H | HIS32 |
| H | HIS80 |
| H | ASP170 |
| H | HIS174 |
| H | HOH405 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 302 |
| Chain | Residue |
| H | LYS125 |
| H | VAL150 |
| H | THR151 |
| site_id | CC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 303 |
| Chain | Residue |
| H | SER102 |
| H | ALA103 |
| H | SER205 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN I 301 |
| Chain | Residue |
| I | HIS32 |
| I | HIS80 |
| I | ASP170 |
| I | HIS174 |
| I | HOH419 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 I 302 |
| Chain | Residue |
| I | LYS125 |
| I | VAL150 |
| I | THR151 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 I 303 |
| Chain | Residue |
| I | SER102 |
| I | ALA103 |
| I | SER205 |
| I | HOH408 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN J 301 |
| Chain | Residue |
| J | HOH407 |
| J | HIS32 |
| J | HIS80 |
| J | ASP170 |
| J | HIS174 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 J 302 |
| Chain | Residue |
| I | ARG58 |
| J | ILE8 |
| J | SER9 |
| J | HIS77 |
| J | HOH408 |
| site_id | DC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 J 303 |
| Chain | Residue |
| J | SER102 |
| J | ALA103 |
| J | SER205 |
| J | HOH475 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN K 301 |
| Chain | Residue |
| K | HIS32 |
| K | HIS80 |
| K | ASP170 |
| K | HIS174 |
| K | HOH406 |
| site_id | DC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 K 302 |
| Chain | Residue |
| K | SER102 |
| K | ALA103 |
| K | SER205 |
| K | HOH402 |
| K | HOH464 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN L 301 |
| Chain | Residue |
| L | HIS32 |
| L | HIS80 |
| L | ASP170 |
| L | HIS174 |
| L | HOH435 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 L 302 |
| Chain | Residue |
| L | LYS125 |
| L | VAL150 |
| L | THR151 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 L 303 |
| Chain | Residue |
| J | ASN182 |
| J | VAL183 |
| L | LYS35 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN M 301 |
| Chain | Residue |
| M | HIS32 |
| M | HIS80 |
| M | ASP170 |
| M | HIS174 |
| M | HOH411 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 M 302 |
| Chain | Residue |
| M | ALA16 |
| M | LEU17 |
| M | HOH448 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 M 303 |
| Chain | Residue |
| M | SER102 |
| M | ALA103 |
| M | SER205 |
| M | HOH423 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN N 301 |
| Chain | Residue |
| N | HIS32 |
| N | HIS80 |
| N | ASP170 |
| N | HIS174 |
| N | HOH402 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 N 302 |
| Chain | Residue |
| N | LYS125 |
| N | VAL150 |
| N | THR151 |
| site_id | EC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN O 301 |
| Chain | Residue |
| O | HIS32 |
| O | HIS80 |
| O | ASP170 |
| O | HIS174 |
| O | HOH410 |
| site_id | EC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 O 302 |
| Chain | Residue |
| O | ALA16 |
| O | LEU17 |
| site_id | EC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 O 303 |
| Chain | Residue |
| O | SER102 |
| O | ALA103 |
| O | SER205 |
| site_id | EC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN P 301 |
| Chain | Residue |
| P | HIS32 |
| P | HIS80 |
| P | ASP170 |
| P | HIS174 |
| P | HOH402 |
Functional Information from PROSITE/UniProt
| site_id | PS00088 |
| Number of Residues | 8 |
| Details | SOD_MN Manganese and iron superoxide dismutases signature. DaWEHAYY |
| Chain | Residue | Details |
| A | ASP170-TYR177 |
