Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GUN

Crystal Structure of the K184R, L185P mutant manganese superoxide dismutase from Candida albicans cytosol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004784	molecular_function	superoxide dismutase activity
A	0005739	cellular_component	mitochondrion
A	0006801	biological_process	superoxide metabolic process
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004784	molecular_function	superoxide dismutase activity
B	0005739	cellular_component	mitochondrion
B	0006801	biological_process	superoxide metabolic process
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004784	molecular_function	superoxide dismutase activity
C	0005739	cellular_component	mitochondrion
C	0006801	biological_process	superoxide metabolic process
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004784	molecular_function	superoxide dismutase activity
D	0005739	cellular_component	mitochondrion
D	0006801	biological_process	superoxide metabolic process
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification
E	0004784	molecular_function	superoxide dismutase activity
E	0005739	cellular_component	mitochondrion
E	0006801	biological_process	superoxide metabolic process
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0019430	biological_process	removal of superoxide radicals
E	0046872	molecular_function	metal ion binding
E	0098869	biological_process	cellular oxidant detoxification
F	0004784	molecular_function	superoxide dismutase activity
F	0005739	cellular_component	mitochondrion
F	0006801	biological_process	superoxide metabolic process
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0019430	biological_process	removal of superoxide radicals
F	0046872	molecular_function	metal ion binding
F	0098869	biological_process	cellular oxidant detoxification
G	0004784	molecular_function	superoxide dismutase activity
G	0005739	cellular_component	mitochondrion
G	0006801	biological_process	superoxide metabolic process
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0019430	biological_process	removal of superoxide radicals
G	0046872	molecular_function	metal ion binding
G	0098869	biological_process	cellular oxidant detoxification
H	0004784	molecular_function	superoxide dismutase activity
H	0005739	cellular_component	mitochondrion
H	0006801	biological_process	superoxide metabolic process
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0019430	biological_process	removal of superoxide radicals
H	0046872	molecular_function	metal ion binding
H	0098869	biological_process	cellular oxidant detoxification
I	0004784	molecular_function	superoxide dismutase activity
I	0005739	cellular_component	mitochondrion
I	0006801	biological_process	superoxide metabolic process
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0019430	biological_process	removal of superoxide radicals
I	0046872	molecular_function	metal ion binding
I	0098869	biological_process	cellular oxidant detoxification
J	0004784	molecular_function	superoxide dismutase activity
J	0005739	cellular_component	mitochondrion
J	0006801	biological_process	superoxide metabolic process
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0019430	biological_process	removal of superoxide radicals
J	0046872	molecular_function	metal ion binding
J	0098869	biological_process	cellular oxidant detoxification
K	0004784	molecular_function	superoxide dismutase activity
K	0005739	cellular_component	mitochondrion
K	0006801	biological_process	superoxide metabolic process
K	0016209	molecular_function	antioxidant activity
K	0016491	molecular_function	oxidoreductase activity
K	0019430	biological_process	removal of superoxide radicals
K	0046872	molecular_function	metal ion binding
K	0098869	biological_process	cellular oxidant detoxification
L	0004784	molecular_function	superoxide dismutase activity
L	0005739	cellular_component	mitochondrion
L	0006801	biological_process	superoxide metabolic process
L	0016209	molecular_function	antioxidant activity
L	0016491	molecular_function	oxidoreductase activity
L	0019430	biological_process	removal of superoxide radicals
L	0046872	molecular_function	metal ion binding
L	0098869	biological_process	cellular oxidant detoxification
M	0004784	molecular_function	superoxide dismutase activity
M	0005739	cellular_component	mitochondrion
M	0006801	biological_process	superoxide metabolic process
M	0016209	molecular_function	antioxidant activity
M	0016491	molecular_function	oxidoreductase activity
M	0019430	biological_process	removal of superoxide radicals
M	0046872	molecular_function	metal ion binding
M	0098869	biological_process	cellular oxidant detoxification
N	0004784	molecular_function	superoxide dismutase activity
N	0005739	cellular_component	mitochondrion
N	0006801	biological_process	superoxide metabolic process
N	0016209	molecular_function	antioxidant activity
N	0016491	molecular_function	oxidoreductase activity
N	0019430	biological_process	removal of superoxide radicals
N	0046872	molecular_function	metal ion binding
N	0098869	biological_process	cellular oxidant detoxification
O	0004784	molecular_function	superoxide dismutase activity
O	0005739	cellular_component	mitochondrion
O	0006801	biological_process	superoxide metabolic process
O	0016209	molecular_function	antioxidant activity
O	0016491	molecular_function	oxidoreductase activity
O	0019430	biological_process	removal of superoxide radicals
O	0046872	molecular_function	metal ion binding
O	0098869	biological_process	cellular oxidant detoxification
P	0004784	molecular_function	superoxide dismutase activity
P	0005739	cellular_component	mitochondrion
P	0006801	biological_process	superoxide metabolic process
P	0016209	molecular_function	antioxidant activity
P	0016491	molecular_function	oxidoreductase activity
P	0019430	biological_process	removal of superoxide radicals
P	0046872	molecular_function	metal ion binding
P	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 301

Chain	Residue
A	HIS32
A	HIS80
A	ASP170
A	HIS174
A	HOH423

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	SER102
A	ALA103
A	SER205

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN B 301

Chain	Residue
B	HIS80
B	ASP170
B	HIS174
B	HOH403
B	HIS32

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	ALA103
B	SER205
B	HOH406

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN C 301

Chain	Residue
C	HIS32
C	HIS80
C	ASP170
C	HIS174
C	HOH404

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	LYS125
C	VAL150
C	THR151

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	SER102
C	ALA103
C	SER205

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN D 301

Chain	Residue
D	HIS32
D	HIS80
D	ASP170
D	HIS174
D	HOH411

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	SER102
D	ALA103
D	SER205
D	HOH425

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
B	ARG58
D	ILE8
D	SER9
D	HIS77

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN E 301

Chain	Residue
E	HIS32
E	HIS80
E	ASP170
E	HIS174
E	HOH407

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 302

Chain	Residue
E	ALA16
E	LEU17

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 303

Chain	Residue
E	SER102
E	ALA103
E	SER205

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN F 301

Chain	Residue
F	HIS32
F	HIS80
F	ASP170
F	HIS174
F	HOH417

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 302

Chain	Residue
F	LYS125
F	VAL150
F	THR151

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 303

Chain	Residue
F	SER102
F	ALA103
F	SER205
F	HOH413

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN G 301

Chain	Residue
G	HIS32
G	HIS80
G	ASP170
G	HIS174
G	HOH426

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 G 302

Chain	Residue
G	ALA16
G	LEU17

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 G 303

Chain	Residue
G	SER102
G	ALA103
G	SER205

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN H 301

Chain	Residue
H	HIS32
H	HIS80
H	ASP170
H	HIS174
H	HOH405

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 302

Chain	Residue
H	LYS125
H	VAL150
H	THR151

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 H 303

Chain	Residue
H	SER102
H	ALA103
H	SER205

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN I 301

Chain	Residue
I	HIS32
I	HIS80
I	ASP170
I	HIS174
I	HOH419

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 I 302

Chain	Residue
I	LYS125
I	VAL150
I	THR151

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 303

Chain	Residue
I	SER102
I	ALA103
I	SER205
I	HOH408

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN J 301

Chain	Residue
J	HOH407
J	HIS32
J	HIS80
J	ASP170
J	HIS174

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 J 302

Chain	Residue
I	ARG58
J	ILE8
J	SER9
J	HIS77
J	HOH408

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 J 303

Chain	Residue
J	SER102
J	ALA103
J	SER205
J	HOH475

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN K 301

Chain	Residue
K	HIS32
K	HIS80
K	ASP170
K	HIS174
K	HOH406

site_id	DC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 K 302

Chain	Residue
K	SER102
K	ALA103
K	SER205
K	HOH402
K	HOH464

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN L 301

Chain	Residue
L	HIS32
L	HIS80
L	ASP170
L	HIS174
L	HOH435

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 302

Chain	Residue
L	LYS125
L	VAL150
L	THR151

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 303

Chain	Residue
J	ASN182
J	VAL183
L	LYS35

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN M 301

Chain	Residue
M	HIS32
M	HIS80
M	ASP170
M	HIS174
M	HOH411

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 M 302

Chain	Residue
M	ALA16
M	LEU17
M	HOH448

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 M 303

Chain	Residue
M	SER102
M	ALA103
M	SER205
M	HOH423

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN N 301

Chain	Residue
N	HIS32
N	HIS80
N	ASP170
N	HIS174
N	HOH402

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 N 302

Chain	Residue
N	LYS125
N	VAL150
N	THR151

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN O 301

Chain	Residue
O	HIS32
O	HIS80
O	ASP170
O	HIS174
O	HOH410

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 O 302

Chain	Residue
O	ALA16
O	LEU17

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 O 303

Chain	Residue
O	SER102
O	ALA103
O	SER205

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN P 301

Chain	Residue
P	HIS32
P	HIS80
P	ASP170
P	HIS174
P	HOH402

Functional Information from PROSITE/UniProt

site_id	PS00088
Number of Residues	8
Details	SOD_MN Manganese and iron superoxide dismutases signature. DaWEHAYY

Chain	Residue	Details
A	ASP170-TYR177

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)