4GOM

Crystal Structure of E. coli DNA Adenine Methyltransferase in Complex with Aza-SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006298	biological_process	mismatch repair
D	0008168	molecular_function	methyltransferase activity
D	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
D	0009307	biological_process	DNA restriction-modification system
D	0009411	biological_process	response to UV
D	0016740	molecular_function	transferase activity
D	0032259	biological_process	methylation
D	0043565	molecular_function	sequence-specific DNA binding
D	1902328	biological_process	bacterial-type DNA replication initiation
D	1904047	molecular_function	S-adenosyl-L-methionine binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0006260	biological_process	DNA replication
E	0006261	biological_process	DNA-templated DNA replication
E	0006298	biological_process	mismatch repair
E	0008168	molecular_function	methyltransferase activity
E	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
E	0009307	biological_process	DNA restriction-modification system
E	0009411	biological_process	response to UV
E	0016740	molecular_function	transferase activity
E	0032259	biological_process	methylation
E	0043565	molecular_function	sequence-specific DNA binding
E	1902328	biological_process	bacterial-type DNA replication initiation
E	1904047	molecular_function	S-adenosyl-L-methionine binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0005515	molecular_function	protein binding
F	0006260	biological_process	DNA replication
F	0006261	biological_process	DNA-templated DNA replication
F	0006298	biological_process	mismatch repair
F	0008168	molecular_function	methyltransferase activity
F	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
F	0009307	biological_process	DNA restriction-modification system
F	0009411	biological_process	response to UV
F	0016740	molecular_function	transferase activity
F	0032259	biological_process	methylation
F	0043565	molecular_function	sequence-specific DNA binding
F	1902328	biological_process	bacterial-type DNA replication initiation
F	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 0Y0 D 301

Chain	Residue
D	TRP10
D	TYR184
D	PHE35
D	ASP54
D	ILE55
D	SER164
D	TYR165
D	ASP181
D	PRO182
D	PRO183

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0Y0 E 301

Chain	Residue
E	TRP10
E	ALA11
E	PRO34
E	PHE35
E	ASP54
E	ILE55
E	SER164
E	TYR165
E	ASP181
E	PRO182
E	PRO183
E	TYR184

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 0Y0 F 301

Chain	Residue
F	TRP10
F	ALA11
F	PRO34
F	PHE35
F	GLY37
F	ASP54
F	ILE55
F	TYR165
F	ASP181
F	PRO182
F	PRO183
F	TYR184

---

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VYCDPPY

Chain	Residue	Details
D	VAL178-TYR184

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---