Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GOK

The Crystal structure of Arl2GppNHp in complex with UNC119a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005813	cellular_component	centrosome
A	0005814	cellular_component	centriole
A	0006110	biological_process	regulation of glycolytic process
A	0006457	biological_process	protein folding
A	0007098	biological_process	centrosome cycle
A	0010811	biological_process	positive regulation of cell-substrate adhesion
A	0015630	cellular_component	microtubule cytoskeleton
A	0015870	biological_process	acetylcholine transport
A	0016328	cellular_component	lateral plasma membrane
A	0019003	molecular_function	GDP binding
A	0031113	biological_process	regulation of microtubule polymerization
A	0031116	biological_process	positive regulation of microtubule polymerization
A	0034260	biological_process	negative regulation of GTPase activity
A	0036064	cellular_component	ciliary basal body
A	0051457	biological_process	maintenance of protein location in nucleus
A	0070830	biological_process	bicellular tight junction assembly
A	0097225	cellular_component	sperm midpiece
A	1903715	biological_process	regulation of aerobic respiration
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005813	cellular_component	centrosome
B	0005814	cellular_component	centriole
B	0006110	biological_process	regulation of glycolytic process
B	0006457	biological_process	protein folding
B	0007098	biological_process	centrosome cycle
B	0010811	biological_process	positive regulation of cell-substrate adhesion
B	0015630	cellular_component	microtubule cytoskeleton
B	0015870	biological_process	acetylcholine transport
B	0016328	cellular_component	lateral plasma membrane
B	0019003	molecular_function	GDP binding
B	0031113	biological_process	regulation of microtubule polymerization
B	0031116	biological_process	positive regulation of microtubule polymerization
B	0034260	biological_process	negative regulation of GTPase activity
B	0036064	cellular_component	ciliary basal body
B	0051457	biological_process	maintenance of protein location in nucleus
B	0070830	biological_process	bicellular tight junction assembly
B	0097225	cellular_component	sperm midpiece
B	1903715	biological_process	regulation of aerobic respiration
C	0000281	biological_process	mitotic cytokinesis
C	0000922	cellular_component	spindle pole
C	0005515	molecular_function	protein binding
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0006897	biological_process	endocytosis
C	0007268	biological_process	chemical synaptic transmission
C	0007399	biological_process	nervous system development
C	0007601	biological_process	visual perception
C	0007602	biological_process	phototransduction
C	0008289	molecular_function	lipid binding
C	0015031	biological_process	protein transport
C	0042953	biological_process	lipoprotein transport
C	0045171	cellular_component	intercellular bridge
C	0045202	cellular_component	synapse
C	0051233	cellular_component	spindle midzone
C	0061098	biological_process	positive regulation of protein tyrosine kinase activity
C	1900186	biological_process	negative regulation of clathrin-dependent endocytosis
C	2001287	biological_process	negative regulation of caveolin-mediated endocytosis
G	0000281	biological_process	mitotic cytokinesis
G	0000922	cellular_component	spindle pole
G	0005515	molecular_function	protein binding
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0006897	biological_process	endocytosis
G	0007268	biological_process	chemical synaptic transmission
G	0007399	biological_process	nervous system development
G	0007601	biological_process	visual perception
G	0007602	biological_process	phototransduction
G	0008289	molecular_function	lipid binding
G	0015031	biological_process	protein transport
G	0042953	biological_process	lipoprotein transport
G	0045171	cellular_component	intercellular bridge
G	0045202	cellular_component	synapse
G	0051233	cellular_component	spindle midzone
G	0061098	biological_process	positive regulation of protein tyrosine kinase activity
G	1900186	biological_process	negative regulation of clathrin-dependent endocytosis
G	2001287	biological_process	negative regulation of caveolin-mediated endocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GNP B 201

Chain	Residue
B	ASP25
B	ASN125
B	LYS126
B	ASP128
B	LEU129
B	SER158
B	ALA159
B	VAL160
B	MG202
B	HOH301
B	HOH302
B	ASN26
B	ALA27
B	GLY28
B	LYS29
B	THR30
B	THR31
B	THR47
B	GLY69

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 202

Chain	Residue
B	THR30
B	THR47
B	ASP66
B	GNP201
B	HOH301
B	HOH302

site_id	AC3
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GNP A 201

Chain	Residue
A	ASP25
A	ASN26
A	ALA27
A	GLY28
A	LYS29
A	THR30
A	THR31
A	THR47
A	GLY69
A	ASN125
A	LYS126
A	ASP128
A	LEU129
A	SER158
A	ALA159
A	VAL160
A	MG202
A	HOH301
A	HOH302
A	HOH303

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 202

Chain	Residue
A	THR30
A	THR47
A	ASP66
A	GNP201
A	HOH301
A	HOH302

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11980706","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P36404","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 628

Chain	Residue	Details
A	LEU70	electrostatic stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 628

Chain	Residue	Details
C	GLN55	electrostatic stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)