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4GOK

The Crystal structure of Arl2GppNHp in complex with UNC119a

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005925cellular_componentfocal adhesion
A0006110biological_processregulation of glycolytic process
A0006457biological_processprotein folding
A0007098biological_processcentrosome cycle
A0010811biological_processpositive regulation of cell-substrate adhesion
A0015630cellular_componentmicrotubule cytoskeleton
A0015870biological_processacetylcholine transport
A0016328cellular_componentlateral plasma membrane
A0019003molecular_functionGDP binding
A0031113biological_processregulation of microtubule polymerization
A0031116biological_processpositive regulation of microtubule polymerization
A0034260biological_processnegative regulation of GTPase activity
A0051457biological_processmaintenance of protein location in nucleus
A0070830biological_processbicellular tight junction assembly
A1903715biological_processregulation of aerobic respiration
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005925cellular_componentfocal adhesion
B0006110biological_processregulation of glycolytic process
B0006457biological_processprotein folding
B0007098biological_processcentrosome cycle
B0010811biological_processpositive regulation of cell-substrate adhesion
B0015630cellular_componentmicrotubule cytoskeleton
B0015870biological_processacetylcholine transport
B0016328cellular_componentlateral plasma membrane
B0019003molecular_functionGDP binding
B0031113biological_processregulation of microtubule polymerization
B0031116biological_processpositive regulation of microtubule polymerization
B0034260biological_processnegative regulation of GTPase activity
B0051457biological_processmaintenance of protein location in nucleus
B0070830biological_processbicellular tight junction assembly
B1903715biological_processregulation of aerobic respiration
C0000281biological_processmitotic cytokinesis
C0000922cellular_componentspindle pole
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0006897biological_processendocytosis
C0007268biological_processchemical synaptic transmission
C0007399biological_processnervous system development
C0007601biological_processvisual perception
C0007602biological_processphototransduction
C0008289molecular_functionlipid binding
C0015031biological_processprotein transport
C0042953biological_processlipoprotein transport
C0045171cellular_componentintercellular bridge
C0045202cellular_componentsynapse
C0051233cellular_componentspindle midzone
C0061098biological_processpositive regulation of protein tyrosine kinase activity
C1900186biological_processnegative regulation of clathrin-dependent endocytosis
C2001287biological_processnegative regulation of caveolin-mediated endocytosis
G0000281biological_processmitotic cytokinesis
G0000922cellular_componentspindle pole
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005813cellular_componentcentrosome
G0005819cellular_componentspindle
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0006897biological_processendocytosis
G0007268biological_processchemical synaptic transmission
G0007399biological_processnervous system development
G0007601biological_processvisual perception
G0007602biological_processphototransduction
G0008289molecular_functionlipid binding
G0015031biological_processprotein transport
G0042953biological_processlipoprotein transport
G0045171cellular_componentintercellular bridge
G0045202cellular_componentsynapse
G0051233cellular_componentspindle midzone
G0061098biological_processpositive regulation of protein tyrosine kinase activity
G1900186biological_processnegative regulation of clathrin-dependent endocytosis
G2001287biological_processnegative regulation of caveolin-mediated endocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE GNP B 201
ChainResidue
BASP25
BASN125
BLYS126
BASP128
BLEU129
BSER158
BALA159
BVAL160
BMG202
BHOH301
BHOH302
BASN26
BALA27
BGLY28
BLYS29
BTHR30
BTHR31
BTHR47
BGLY69

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 202
ChainResidue
BTHR30
BTHR47
BASP66
BGNP201
BHOH301
BHOH302

site_idAC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE GNP A 201
ChainResidue
AASP25
AASN26
AALA27
AGLY28
ALYS29
ATHR30
ATHR31
ATHR47
AGLY69
AASN125
ALYS126
AASP128
ALEU129
ASER158
AALA159
AVAL160
AMG202
AHOH301
AHOH302
AHOH303

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 202
ChainResidue
ATHR30
ATHR47
AASP66
AGNP201
AHOH301
AHOH302

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING:
ChainResidueDetails
AGLY68
AASN125
BGLY68
BASN125
AGLY23
AASP66
GTYR131
CTYR131

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:31696965
ChainResidueDetails
GSER37
GSER39
GSER41
CSER37
CSER39
CSER41

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P36404
ChainResidueDetails
ALYS71
BLYS71

Catalytic Information from CSA
site_idMCSA1
Number of Residues1
DetailsM-CSA 628
ChainResidueDetails
BLEU70electrostatic stabiliser

site_idMCSA2
Number of Residues1
DetailsM-CSA 628
ChainResidueDetails
ALEU70electrostatic stabiliser

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PDB entries from 2024-06-12

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