Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GO4

Crystal structure of PnpE in complex with Nicotinamide adenine dinucleotide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0000166	molecular_function	nucleotide binding
C	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0000166	molecular_function	nucleotide binding
D	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
E	0000166	molecular_function	nucleotide binding
E	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
E	0016491	molecular_function	oxidoreductase activity
E	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
F	0000166	molecular_function	nucleotide binding
F	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
F	0016491	molecular_function	oxidoreductase activity
F	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
G	0000166	molecular_function	nucleotide binding
G	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
G	0016491	molecular_function	oxidoreductase activity
G	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
H	0000166	molecular_function	nucleotide binding
H	0004030	molecular_function	aldehyde dehydrogenase [NAD(P)+] activity
H	0016491	molecular_function	oxidoreductase activity
H	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD A 601

Chain	Residue
A	ILE145
A	GLY205
A	GLY209
A	GLN210
A	PHE223
A	THR224
A	GLY225
A	SER226
A	THR229
A	GLU247
A	LEU248
A	VAL146
A	GLY249
A	CYS281
A	GLU381
A	PHE383
A	LEU409
A	PHE447
C	HOH716
A	TRP148
A	ASN149
A	PHE154
A	LYS172
A	PRO173
A	SER174
A	GLU175

site_id	AC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD B 601

Chain	Residue
B	ILE145
B	VAL146
B	PRO147
B	TRP148
B	ASN149
B	PHE154
B	LYS172
B	PRO173
B	SER174
B	GLU175
B	GLY205
B	GLY209
B	GLN210
B	PHE223
B	THR224
B	GLY225
B	SER226
B	THR229
B	GLU247
B	LEU248
B	GLY249
B	CYS281
B	ARG328
B	GLU381
B	LEU409
B	PHE447

site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD C 601

Chain	Residue
C	ILE145
C	VAL146
C	PRO147
C	TRP148
C	ASN149
C	PHE154
C	LYS172
C	SER174
C	GLU175
C	GLY205
C	GLY209
C	GLN210
C	PHE223
C	THR224
C	GLY225
C	SER226
C	THR229
C	ILE233
C	GLU247
C	LEU248
C	GLY249
C	CYS281
C	GLU381
C	LEU409
C	PHE447
C	HOH717

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD D 601

Chain	Residue
D	PHE383
D	LEU409
D	PHE447
E	ASP330
D	ILE145
D	VAL146
D	PRO147
D	TRP148
D	ASN149
D	PHE154
D	LYS172
D	GLU175
D	GLY205
D	GLY209
D	GLN210
D	PHE223
D	THR224
D	GLY225
D	SER226
D	THR229
D	GLU247
D	LEU248
D	GLY249
D	CYS281
D	GLU381

site_id	AC5
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD E 601

Chain	Residue
D	ASP330
E	ILE145
E	VAL146
E	PRO147
E	TRP148
E	ASN149
E	PHE154
E	LYS172
E	SER174
E	GLU175
E	GLY205
E	GLY209
E	GLN210
E	PHE223
E	THR224
E	GLY225
E	SER226
E	THR229
E	GLU247
E	LEU248
E	GLY249
E	CYS281
E	GLU381
E	PHE383
E	LEU409
E	PHE447

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD F 601

Chain	Residue
F	ILE145
F	VAL146
F	PRO147
F	TRP148
F	ASN149
F	PHE154
F	LYS172
F	GLU175
F	GLY205
F	GLY209
F	GLN210
F	PHE223
F	THR224
F	GLY225
F	SER226
F	THR229
F	GLU247
F	LEU248
F	GLY249
F	CYS281
F	GLU381
F	LEU409
F	PHE447

site_id	AC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD G 601

Chain	Residue
G	ILE145
G	VAL146
G	PRO147
G	TRP148
G	ASN149
G	PHE154
G	LYS172
G	GLU175
G	GLY205
G	GLY209
G	GLN210
G	PHE223
G	THR224
G	GLY225
G	SER226
G	THR229
G	GLU247
G	LEU248
G	GLY249
G	CYS281
G	GLU381
G	LEU409
G	PHE447
G	HOH705

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD H 601

Chain	Residue
H	VAL146
H	PRO147
H	TRP148
H	ASN149
H	PHE154
H	LYS172
H	SER174
H	GLU175
H	GLY205
H	GLY209
H	GLN210
H	PHE223
H	THR224
H	GLY225
H	SER226
H	THR229
H	GLU247
H	LEU248
H	GLY249
H	CYS281
H	GLU381
H	LEU409
H	PHE447

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FhNQGQACIAGS

Chain	Residue	Details
A	PHE274-SER285

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)