4GNT

Complex of ChREBP and 14-3-3beta

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004860	molecular_function	protein kinase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006605	biological_process	protein targeting
A	0019899	molecular_function	enzyme binding
A	0019904	molecular_function	protein domain specific binding
A	0035308	biological_process	negative regulation of protein dephosphorylation
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042826	molecular_function	histone deacetylase binding
A	0043085	biological_process	positive regulation of catalytic activity
A	0045184	biological_process	establishment of protein localization
A	0045744	biological_process	negative regulation of G protein-coupled receptor signaling pathway
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0051220	biological_process	cytoplasmic sequestering of protein

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 301

Chain	Residue
A	LYS51
A	ARG58
A	ARG129
A	TYR130
A	HOH432
A	HOH433
B	TRP127
B	ARG128

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	GLU37
A	HIS36

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	GLN113
A	ALA114

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	SER39
A	ASN40
A	HOH416
A	HOH454

---

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG43-VAL53

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR213-SER232

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interaction with phosphoserine on interacting protein => ECO:0000250

Chain	Residue	Details
A	ARG58
A	ARG129

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P31946

Chain	Residue	Details
A	MET1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P31946

Chain	Residue	Details
A	THR2

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27348

Chain	Residue	Details
A	LYS5

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P27348

Chain	Residue	Details
A	LYS51

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9705322

Chain	Residue	Details
A	SER60

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P31946

Chain	Residue	Details
A	LYS70
A	LYS117

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: 3'-nitrotyrosine => ECO:0007744|PubMed:16800626

Chain	Residue	Details
A	TYR84
A	TYR106

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68251

Chain	Residue	Details
A	SER186

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P31946

Chain	Residue	Details
A	SER232

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P27348

Chain	Residue	Details
A	LYS51

---