4GMU
Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 34 |
Details | BINDING SITE FOR RESIDUE GTP A 701 |
Chain | Residue |
A | HIS264 |
A | ASP311 |
A | VAL335 |
A | ARG405 |
A | ARG436 |
A | TRP516 |
A | PHE517 |
A | PHE525 |
A | GLY529 |
A | PHE530 |
A | ASN533 |
A | PRO285 |
A | MN702 |
A | MN703 |
A | OXL705 |
A | HOH840 |
A | HOH843 |
A | HOH853 |
A | HOH887 |
A | HOH909 |
A | HOH915 |
A | HOH921 |
A | SER286 |
A | HOH938 |
A | HOH947 |
A | HOH1036 |
A | HOH1209 |
A | HOH1246 |
A | ALA287 |
A | CYS288 |
A | GLY289 |
A | LYS290 |
A | THR291 |
A | ASN292 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 702 |
Chain | Residue |
A | LYS244 |
A | HIS264 |
A | ASP311 |
A | GTP701 |
A | OXL705 |
A | HOH1671 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 703 |
Chain | Residue |
A | THR291 |
A | GTP701 |
A | HOH884 |
A | HOH909 |
A | HOH915 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 704 |
Chain | Residue |
A | LEU79 |
A | ASN208 |
A | HOH834 |
A | HOH903 |
A | HOH1222 |
A | HOH1575 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE OXL A 705 |
Chain | Residue |
A | ARG87 |
A | LYS244 |
A | HIS264 |
A | SER286 |
A | ASP311 |
A | ARG405 |
A | GTP701 |
A | MN702 |
A | HOH842 |
A | HOH1347 |
A | HOH1676 |
A | HOH1677 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MN A 706 |
Chain | Residue |
A | GLU63 |
A | HIS502 |
A | GLU607 |
A | HOH883 |
A | HOH1130 |
A | HOH1507 |
Functional Information from PROSITE/UniProt
site_id | PS00505 |
Number of Residues | 9 |
Details | PEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN |
Chain | Residue | Details |
A | PHE284-ASN292 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:2909519 |
Chain | Residue | Details |
A | CYS288 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17685635, ECO:0000269|PubMed:18772387, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970 |
Chain | Residue | Details |
A | ARG87 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18197707, ECO:0000269|PubMed:18772387, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970 |
Chain | Residue | Details |
A | TYR235 | |
A | ASN403 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17685635, ECO:0000269|PubMed:18197707, ECO:0000269|PubMed:18772387, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26322521, ECO:0000269|PubMed:26709450, ECO:0000269|PubMed:28345895, ECO:0000269|PubMed:31461616, ECO:0007744|PDB:4YW9, ECO:0007744|PDB:5FH0, ECO:0007744|PDB:5FH1, ECO:0007744|PDB:5FH2, ECO:0007744|PDB:5FH3, ECO:0007744|PDB:5FH4, ECO:0007744|PDB:5FH5, ECO:0007744|PDB:5V97, ECO:0007744|PDB:5V9F, ECO:0007744|PDB:5V9G, ECO:0007744|PDB:6P5O |
Chain | Residue | Details |
A | LYS244 | |
A | HIS264 | |
A | ASP311 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17685635, ECO:0000269|PubMed:18197707, ECO:0000269|PubMed:18772387, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970 |
Chain | Residue | Details |
A | SER286 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17685635, ECO:0000269|PubMed:18772387, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26322521, ECO:0000269|PubMed:26709450, ECO:0000269|PubMed:28345895, ECO:0007744|PDB:4YW9, ECO:0007744|PDB:5FH0, ECO:0007744|PDB:5FH1, ECO:0007744|PDB:5FH2, ECO:0007744|PDB:5FH3, ECO:0007744|PDB:5FH4, ECO:0007744|PDB:5V97, ECO:0007744|PDB:5V9F, ECO:0007744|PDB:5V9G |
Chain | Residue | Details |
A | ALA287 | |
A | ARG436 | |
A | PHE530 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:17685635, ECO:0000269|PubMed:20476774, ECO:0000269|PubMed:23127136, ECO:0000269|PubMed:24863970, ECO:0000269|PubMed:26322521, ECO:0000269|PubMed:26709450, ECO:0000269|PubMed:28345895, ECO:0007744|PDB:4YW9, ECO:0007744|PDB:5FH0, ECO:0007744|PDB:5FH1, ECO:0007744|PDB:5FH2, ECO:0007744|PDB:5FH3, ECO:0007744|PDB:5FH4, ECO:0007744|PDB:5V97, ECO:0007744|PDB:5V9F, ECO:0007744|PDB:5V9G |
Chain | Residue | Details |
A | ARG405 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
Chain | Residue | Details |
A | SER19 | |
A | SER118 |
site_id | SWS_FT_FI9 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine; by p300/EP300 => ECO:0000250|UniProtKB:P35558 |
Chain | Residue | Details |
A | LYS70 | |
A | LYS71 | |
A | LYS594 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P35558 |
Chain | Residue | Details |
A | SER90 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; by p300/EP300 => ECO:0000250|UniProtKB:P35558, ECO:0000269|PubMed:30193097 |
Chain | Residue | Details |
A | LYS91 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q16822 |
Chain | Residue | Details |
A | THR178 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q16822 |
Chain | Residue | Details |
A | SER286 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30193097 |
Chain | Residue | Details |
A | LYS521 | |
A | LYS524 |