4GMU

Structure of rat cytosolic PEPCK Ld_1g in complex with oxalate and GTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004611	molecular_function	phosphoenolpyruvate carboxykinase activity
A	0004613	molecular_function	phosphoenolpyruvate carboxykinase (GTP) activity
A	0005525	molecular_function	GTP binding
A	0006094	biological_process	gluconeogenesis
A	0017076	molecular_function	purine nucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	34
Details	BINDING SITE FOR RESIDUE GTP A 701

Chain	Residue
A	HIS264
A	ASP311
A	VAL335
A	ARG405
A	ARG436
A	TRP516
A	PHE517
A	PHE525
A	GLY529
A	PHE530
A	ASN533
A	PRO285
A	MN702
A	MN703
A	OXL705
A	HOH840
A	HOH843
A	HOH853
A	HOH887
A	HOH909
A	HOH915
A	HOH921
A	SER286
A	HOH938
A	HOH947
A	HOH1036
A	HOH1209
A	HOH1246
A	ALA287
A	CYS288
A	GLY289
A	LYS290
A	THR291
A	ASN292

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 702

Chain	Residue
A	LYS244
A	HIS264
A	ASP311
A	GTP701
A	OXL705
A	HOH1671

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 703

Chain	Residue
A	THR291
A	GTP701
A	HOH884
A	HOH909
A	HOH915

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 704

Chain	Residue
A	LEU79
A	ASN208
A	HOH834
A	HOH903
A	HOH1222
A	HOH1575

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE OXL A 705

Chain	Residue
A	ARG87
A	LYS244
A	HIS264
A	SER286
A	ASP311
A	ARG405
A	GTP701
A	MN702
A	HOH842
A	HOH1347
A	HOH1676
A	HOH1677

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 706

Chain	Residue
A	GLU63
A	HIS502
A	GLU607
A	HOH883
A	HOH1130
A	HOH1507

---

Functional Information from PROSITE/UniProt

site_id	PS00505
Number of Residues	9
Details	PEPCK_GTP Phosphoenolpyruvate carboxykinase (GTP) signature. FPSACGKTN

Chain	Residue	Details
A	PHE284-ASN292

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2909519","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31461616","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P5O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18197707","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18772387","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17685635","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20476774","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23127136","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24863970","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26322521","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26709450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28345895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YW9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V9G","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by p300/EP300","evidences":[{"source":"UniProtKB","id":"P35558","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q16822","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"30193097","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---