Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GM5

Carboxypeptidase T with Sulphamoil Arginine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS69
A	GLU72
A	HIS204
A	0X9408

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	HOH748
A	SER7
A	TYR9
A	GLU14
A	HOH578
A	HOH656

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 403

Chain	Residue
A	SER50
A	ASP51
A	GLU57
A	GLU59
A	HOH585

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 404

Chain	Residue
A	TYR5
A	ASP291
A	GLU292
A	HOH628
A	HOH763
A	HOH764

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 405

Chain	Residue
A	ASP56
A	GLU57
A	GLU61
A	GLU104
A	HOH612
A	HOH747

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 406

Chain	Residue
A	PHE174
A	ARG183
A	ASN187
A	TRP264
A	GLN268
A	HOH646
A	HOH681
A	HOH847

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 407

Chain	Residue
A	VAL16
A	ASN20
A	ASN25
A	LYS32
A	TRP45
A	HOH530

site_id	AC8
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 0X9 A 408

Chain	Residue
A	HIS69
A	GLU72
A	ARG129
A	ASN146
A	ARG147
A	HIS204
A	THR205
A	GLY215
A	ALA251
A	TYR255
A	THR257
A	ASP260
A	THR262
A	ASP263
A	THR275
A	GLU277
A	ZN401
A	GOL410
A	SO4416
A	HOH731

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	SER139
A	TYR140
A	GOL423
A	HOH779
A	HOH895

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 410

Chain	Residue
A	TYR206
A	SER207
A	0X9408
A	SO4416

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 411

Chain	Residue
A	ASP1
A	ASN11
A	GLU117
A	ILE120
A	HOH554
A	HOH659
A	HOH785

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 412

Chain	Residue
A	GLY193
A	LYS194
A	GLN195
A	GLN268
A	HIS269
A	HOH632
A	HOH704
A	HOH881

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 413

Chain	Residue
A	PRO3
A	SER4
A	TYR5
A	HOH698
A	HOH761

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 414

Chain	Residue
A	TYR125
A	SER127
A	SER223
A	HOH603
A	HOH635
A	HOH641
A	HOH652

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 415

Chain	Residue
A	PRO134
A	ARG171
A	HOH705
A	HOH755
A	HOH903
A	TYR39
A	GLN133

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 416

Chain	Residue
A	ARG129
A	ARG147
A	GLU166
A	THR167
A	TYR255
A	0X9408
A	GOL410
A	HOH731

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 417

Chain	Residue
A	THR239
A	LYS311
A	HOH617
A	HOH836
A	HOH896

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 418

Chain	Residue
A	GLU14
A	ASN17
A	HOH624
A	HOH719
A	HOH759
A	HOH873

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 419

Chain	Residue
A	PHE33
A	ASP184
A	PHE185
A	HOH887
A	HOH898

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 420

Chain	Residue
A	GLU40
A	GLY41
A	ARG42
A	HOH615
A	HOH672

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 421

Chain	Residue
A	SER138
A	SER139
A	TYR140
A	SER172
A	HOH581
A	HOH904
A	HOH905
A	HOH906

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 422

Chain	Residue
A	THR226
A	GLN227
A	HOH557
A	HOH571
A	HOH863
A	HOH888

site_id	CC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 423

Chain	Residue
A	TRP128
A	SER139
A	TYR140
A	VAL141
A	GOL409
A	HOH527
A	HOH642
A	HOH690
A	HOH706
A	HOH779
A	HOH895

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 424

Chain	Residue
A	LYS48
A	TYR106
A	HOH898
A	HOH899

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 425

Chain	Residue
A	ASN28
A	LYS31
A	HOH725

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 426

Chain	Residue
A	ASN52
A	VAL53
A	GLY54
A	THR55
A	HOH674

site_id	CC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 427

Chain	Residue
A	ARG71
A	GLU166
A	TYR216
A	THR217
A	THR219
A	HOH541
A	HOH550
A	HOH884
A	HOH907
A	HOH908

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PeVlYtaLhHArEhLTVemalyT

Chain	Residue	Details
A	PRO60-THR82

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HTYSELIlYPY

Chain	Residue	Details
A	HIS204-TYR214

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255\|PROSITE-ProRule:PRU01379, ECO:0000305\|PubMed:1521526

Chain	Residue	Details
A	GLU277

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01379, ECO:0000269\|PubMed:1521526

Chain	Residue	Details
A	HIS69
A	GLU72
A	HIS204

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)