4GLO

Crystal structure of a short chain dehydrogenase homolog (target EFI-505321) from burkholderia multivorans, with bound NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006004	biological_process	fucose metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019317	biological_process	fucose catabolic process
B	0000166	molecular_function	nucleotide binding
B	0006004	biological_process	fucose metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019317	biological_process	fucose catabolic process
C	0000166	molecular_function	nucleotide binding
C	0006004	biological_process	fucose metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019317	biological_process	fucose catabolic process
D	0000166	molecular_function	nucleotide binding
D	0006004	biological_process	fucose metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019317	biological_process	fucose catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD A 301

Chain	Residue
A	GLY14
A	TYR117
A	ILE138
A	SER139
A	TYR153
A	LYS157
A	PRO183
A	ALA184
A	VAL186
A	LEU190
A	SO4302
A	SER17
A	HOH435
A	HOH436
A	HOH472
A	HOH473
A	HOH488
A	HOH538
A	HOH632
A	GLY18
A	ILE19
A	ARG39
A	VAL62
A	GLU63
A	LEU64
A	ASN90

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 302

Chain	Residue
A	ASN94
A	SER140
A	LYS141
A	THR142
A	GLN147
A	TYR153
A	ALA184
A	NAD301
A	HOH472
A	HOH563

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	GLN65
A	ARG112
A	HOH537
A	HOH594
A	HOH625

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG132
A	PHE198
A	GLU199
A	HOH534
A	HOH599
A	HOH633
D	ARG217
D	HOH535

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 305

Chain	Residue
A	THR220
A	PRO221
A	ASP222
A	HOH610

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 306

Chain	Residue
A	ALA143
A	GLY158
B	ALA143
B	GLY158

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 307

Chain	Residue
A	THR145
A	TYR250
A	THR251
A	HOH433
C	THR251
C	HIS252
C	LEU253
C	ARG255
C	EDO306

---

site_id	AC8
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD B 301

Chain	Residue
B	GLY14
B	SER17
B	ILE19
B	ARG39
B	VAL62
B	GLU63
B	LEU64
B	ASN90
B	TYR117
B	ILE138
B	SER139
B	SER140
B	TYR153
B	LYS157
B	PRO183
B	ALA184
B	VAL186
B	LEU190
B	SO4302
B	HOH425
B	HOH447
B	HOH459
B	HOH469
B	HOH508
B	HOH515
B	HOH590

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	NAD301
B	HOH469
B	HOH654
B	ASN94
B	SER140
B	LYS141
B	THR142
B	GLN147
B	TYR153
B	ALA184

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	ARG39
B	GLN65
B	ARG112
B	HOH503
B	HOH617

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 304

Chain	Residue
B	THR220
B	PRO221
B	ASP222
B	HOH510

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO B 305

Chain	Residue
B	THR145
B	TYR250
B	THR251
D	THR251
D	HIS252
D	LEU253
D	ARG255
D	EDO305
D	HOH420

---

site_id	BC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD C 301

Chain	Residue
C	GLY14
C	SER17
C	GLY18
C	ILE19
C	GLY20
C	ARG39
C	VAL62
C	GLU63
C	LEU64
C	GLN65
C	ASN90
C	TYR117
C	ILE138
C	SER139
C	SER140
C	TYR153
C	LYS157
C	PRO183
C	ALA184
C	GLU185
C	VAL186
C	THR188
C	PRO189
C	SO4302
C	HOH495
C	HOH567
C	HOH568

---

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 C 302

Chain	Residue
C	ASN94
C	SER140
C	LYS141
C	THR142
C	GLN147
C	TYR153
C	ALA184
C	NAD301
C	HOH488
C	HOH494
C	HOH495

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	ARG39
C	GLN65
C	ARG112

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 304

Chain	Residue
C	THR220
C	PRO221
C	ASP222
C	HOH528
C	HOH549

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO C 305

Chain	Residue
C	ALA143
C	GLY158
D	ALA143
D	GLY158

---

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO C 306

Chain	Residue
A	THR251
A	HIS252
A	LEU253
A	ARG255
A	EDO307
C	THR145
C	TYR250
C	THR251
C	HOH416

---

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 307

Chain	Residue
C	GLY96
C	ILE97
C	GLY98
C	LEU99
C	ASP100
C	ALA101
C	ASN149

---

site_id	CC2
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD D 301

Chain	Residue
D	GLY14
D	SER17
D	GLY18
D	ILE19
D	GLY20
D	ARG39
D	VAL62
D	GLU63
D	LEU64
D	ASN90
D	TYR117
D	ILE138
D	SER139
D	SER140
D	TYR153
D	LYS157
D	PRO183
D	ALA184
D	VAL186
D	THR188
D	SO4302
D	HOH459
D	HOH489
D	HOH543
D	HOH549
D	HOH588

---

site_id	CC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	ASN94
D	SER140
D	LYS141
D	THR142
D	GLN147
D	TYR153
D	ALA184
D	NAD301
D	HOH447
D	HOH489
D	HOH546

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
D	ARG39
D	GLN65
D	ARG112
D	HOH541

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 304

Chain	Residue
D	PRO221
D	ASP222
D	HOH502

---

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO D 305

Chain	Residue
B	THR251
B	HIS252
B	LEU253
B	ARG255
B	EDO305
D	THR145
D	TYR250
D	THR251
D	HOH424

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 306

Chain	Residue
A	ASP226
D	PRO234
D	ARG235
D	SER237
D	HOH481
D	HOH505

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"A7IQH5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	68
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23214453","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GVX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---