4GLL

Crystal structure of human UDP-xylose synthase.

Replaces:  4EF7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042732	biological_process	D-xylose metabolic process
A	0070403	molecular_function	NAD+ binding
B	0042732	biological_process	D-xylose metabolic process
B	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD A 800

Chain	Residue
A	GLY95
A	THR123
A	GLY124
A	HIS143
A	ASP144
A	VAL145
A	LEU159
A	ALA160
A	SER161
A	ALA163
A	THR178
A	ALA97
A	SER201
A	TYR231
A	LYS235
A	ILE258
A	THR261
A	HIS267
A	HOH940
A	GLY98
A	PHE99
A	VAL100
A	ASP119
A	ASN120
A	PHE121
A	PHE122

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GAI A 801

Chain	Residue
A	THR288
A	TYR290
A	ILE331
A	ASP356

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 802

Chain	Residue
A	SER203
A	PHE259
A	ASN260
A	GLN359
A	ARG361

---

site_id	AC4
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAD B 501

Chain	Residue
B	GLY95
B	GLY98
B	PHE99
B	VAL100
B	ASP119
B	ASN120
B	PHE121
B	PHE122
B	THR123
B	GLY124
B	HIS143
B	ASP144
B	VAL145
B	LEU159
B	ALA160
B	SER161
B	PRO162
B	ALA163
B	LYS174
B	THR178
B	ALA200
B	THR202
B	TYR231
B	LYS235
B	ILE258
B	PHE259
B	ASN260
B	THR261
B	HIS267
B	ARG272
B	HOH608

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GAI B 502

Chain	Residue
B	THR288
B	TYR290
B	ASP356

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 503

Chain	Residue
B	TYR150
B	ARG192
B	TYR290
B	SER292
B	GLY293
B	SER294
B	GLN295

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23656592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22810237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B69","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22810237","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2B69","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25521717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4LK3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4M55","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---