4GK1

Crystal structure of CD23 lectin domain mutant D270A

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 301

Chain	Residue
A	ARG263
A	GLY264
A	SER265

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	LYS179
A	SER215
A	HIS216

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS276
A	THR181
A	GLN183
A	HIS186

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG172
A	LYS173
A	HIS202
A	GLU206
A	HOH425

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	ASN225
A	LEU228
A	ARG253
A	GLN255
A	GLY256
A	ASP258
A	HOH435
B	ARG224

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 301

Chain	Residue
A	HIS186
B	ARG172
B	LEU285
B	HOH458

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
A	ARG224
A	LEU226
B	ARG188
B	ASP192
B	GLN197
B	VAL235
B	HOH423
B	HOH435

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
B	ARG172
B	LYS173
B	HIS202
B	GLU206
B	HOH477

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	ARG263
B	ASN269
B	ARG275
B	HOH461
E	HIS216

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 305

Chain	Residue
B	ARG263
B	SER265
B	ARG267
B	HOH452
E	SER215
E	HIS216
E	THR217

---

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B 306

Chain	Residue
B	LYS229
B	GLU231
B	ILE233
B	HIS239
D	ASN225
D	ARG253
D	GLN255
D	GLY256
D	ASP258
D	HOH455

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 301

Chain	Residue
C	CYS163
C	ILE168
C	ASN169
C	HOH476

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 302

Chain	Residue
C	ARG263
C	GLY264
C	SER265
C	ARG267
C	HOH462

---

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 C 303

Chain	Residue
C	ASN225
C	LEU228
C	ARG253
C	GLY256
C	ASP258
C	HOH415
C	HOH425
C	HOH441
C	HOH461
E	ARG224

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 304

Chain	Residue
C	ARG172
C	LYS173
C	HIS202
C	GLU206
C	HOH418

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 305

Chain	Residue
C	ARG284
C	HOH416
C	HOH464
D	ARG267

---

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 306

Chain	Residue
C	GLN183
C	HIS186
C	LYS276

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 301

Chain	Residue
D	ARG263
D	GLY264
D	SER265

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 302

Chain	Residue
D	ARG275
D	HOH460
D	GLU257
D	ASN269
D	ALA270

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
D	ARG188
D	ARG224
D	HOH445

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 304

Chain	Residue
D	ARG188
D	ASP192
D	GLN197
D	HOH419
F	ARG172

---

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 301

Chain	Residue
C	HIS186
E	ARG172
E	LEU285

---

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 302

Chain	Residue
E	ASN225
E	ASP227
E	ARG253
E	GLN255
E	GLY256
E	ASP258

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 303

Chain	Residue
E	ARG172
E	LYS173
E	HIS202
E	GLU206
E	HOH449

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 304

Chain	Residue
E	ARG263
E	SER265
E	ARG267
E	HOH423

---

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 305

Chain	Residue
C	ARG224
C	LEU226
E	ARG188
E	ASP192
E	GLN197
E	VAL235
E	HOH420
E	HOH455

---

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL F 301

Chain	Residue
C	PRO247
D	ASP193
F	VAL159
F	THR289
F	PRO290

---

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL F 302

Chain	Residue
F	ARG263
F	GLY264
F	SER265

---

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL F 303

Chain	Residue
C	ARG275
F	ARG275
F	LYS276

---

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 F 304

Chain	Residue
E	LYS229
E	GLU231
E	HIS239
F	ASN225
F	ARG253
F	GLN255
F	GLY256
F	ASP258
F	HOH429

---

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 305

Chain	Residue
D	ARG172
F	ARG188
F	ASP192
F	GLN197
F	VAL235
F	HOH420
F	HOH431

---

site_id	DC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 306

Chain	Residue
A	ARG284
F	ARG267

---

site_id	DC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 307

Chain	Residue
F	LYS182
F	GLN183
F	HIS186
F	LYS276
F	HOH463

---

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 308

Chain	Residue
B	LYS166
F	LYS179
F	HIS216
F	HOH451

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 309

Chain	Residue
A	GLU195
F	ARG267
F	HOH417
F	HOH457

---

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL G 301

Chain	Residue
G	ARG188
G	ARG224
G	LEU226
G	ASP227

---

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 G 302

Chain	Residue
G	LEU228
G	ARG253
G	GLN255
G	GLY256
G	ASP258

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	854
Details	Domain: {"description":"C-type lectin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00040","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16765898","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---