4GF7

Crystal structure of 2-Methyl-3-hydroxypyridine-5-carboxylic acid oxygenase (MHPCO), unliganded form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0047081	molecular_function	3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	BINDING SITE FOR RESIDUE FAD A 401

Chain	Residue
A	GLY18
A	TYR54
A	ARG106
A	SER128
A	GLU129
A	ALA130
A	ALA155
A	ASP156
A	LEU179
A	ARG181
A	GLY287
A	GLY19
A	ASP288
A	PRO295
A	ALA298
A	GLY300
A	ALA301
A	GLY302
A	HOH501
A	HOH507
A	HOH515
A	HOH522
A	GLY20
A	HOH526
A	HOH537
A	HOH567
A	HOH578
A	HOH757
A	HOH774
A	HOH837
A	PHE21
A	ALA22
A	HIS40
A	GLU41
A	LYS42
A	ILE53

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BME A 402

Chain	Residue
A	TRP173
A	TYR270
A	CYS294
A	ALA347
A	HOH563
A	HOH630
A	HOH667

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	LEU73
A	GLN74
A	GLY75
A	SER76
A	ASN97
A	ARG102
A	PRO378
A	HOH569
A	HOH656
A	HOH657
A	HOH769

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 404

Chain	Residue
A	LYS169
A	ASP171
A	LYS274
A	ASP276
A	HOH633

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 405

Chain	Residue
A	GLU364
A	ARG367
A	TYR375

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 406

Chain	Residue
A	ARG331
A	ARG373
A	TYR375
A	HOH593
A	HOH934

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 407

Chain	Residue
A	ASN356
A	THR359
A	PRO360
A	HOH520

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site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG A 408

Chain	Residue
A	ASN88
A	PRO207
A	GLU247
A	HOH539
A	HOH848

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