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4GEW

Crystal structure of TDP2 from C. elegans

Functional Information from GO Data
ChainGOidnamespacecontents
A0003697molecular_functionsingle-stranded DNA binding
A0003824molecular_functioncatalytic activity
A0004518molecular_functionnuclease activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0016605cellular_componentPML body
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0070260molecular_function5'-tyrosyl-DNA phosphodiesterase activity
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 401
ChainResidue
AASP31
AGLU158
AHIS232
ASER235
AASP271
AASN273
ATRP303
APHE321
AHIS353

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 402
ChainResidue
ALYS175
AILE176
AHOH572

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 403
ChainResidue
AGLY285
ATRP326
AGLY328
ALEU330
AASP331

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 404
ChainResidue
AASN150
APRO151
AASP152
ASER192

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 405
ChainResidue
AALA141
AGLN341
AILE343
AHOH541

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 406
ChainResidue
AILE176
ATYR177
ATYR178
AHIS200
AHOH636

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 407
ChainResidue
AALA292
ALYS332
AVAL333

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 408
ChainResidue
AGLU113
APRO329

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 409
ChainResidue
AGLU113
ALEU115
AARG342

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:O95551
ChainResidueDetails
AASP271

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:23104058, ECO:0007744|PDB:4FVA
ChainResidueDetails
AASP128
AGLU158

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Interaction with 5' end of substrate DNA => ECO:0000250|UniProtKB:Q9JJX7
ChainResidueDetails
ATYR185
ATRP303
APHE321
AHIS353

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PDB entries from 2024-10-30

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