4GED
Crystal Structure of the Leishmania Major Peroxidase-Cytochrome C Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004601 | molecular_function | peroxidase activity |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0020037 | molecular_function | heme binding |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0022904 | biological_process | respiratory electron transport chain |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE HEM A 401 |
| Chain | Residue |
| A | PRO60 |
| A | HIS198 |
| A | PHE201 |
| A | SER202 |
| A | TRP208 |
| A | SER252 |
| A | HOH501 |
| A | HOH512 |
| A | HOH561 |
| A | HOH663 |
| A | TRP67 |
| A | PRO162 |
| A | LEU188 |
| A | ALA191 |
| A | HIS192 |
| A | GLY195 |
| A | GLU196 |
| A | CYS197 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 402 |
| Chain | Residue |
| A | THR193 |
| A | THR209 |
| A | ASP211 |
| A | GLY214 |
| A | ASP216 |
| A | SER218 |
| A | HOH569 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 403 |
| Chain | Residue |
| A | GLU69 |
| A | SER72 |
| A | GLY80 |
| A | SER81 |
| A | SER86 |
| A | GLU92 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEC B 201 |
| Chain | Residue |
| B | ARG24 |
| B | ALA25 |
| B | CYS28 |
| B | HIS29 |
| B | VAL39 |
| B | ILE46 |
| B | SER51 |
| B | GLY52 |
| B | VAL54 |
| B | TYR59 |
| B | SER60 |
| B | ASN63 |
| B | TRP70 |
| B | LEU75 |
| B | LEU79 |
| B | THR89 |
| B | LYS90 |
| B | MET91 |
| B | SER92 |
| B | PHE93 |
| B | ILE96 |
| B | HOH302 |
Functional Information from PROSITE/UniProt
| site_id | PS00436 |
| Number of Residues | 12 |
| Details | PEROXIDASE_2 Peroxidases active site signature. GPslIRLaWHEA |
| Chain | Residue | Details |
| A | GLY59-ALA70 |
