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4GED

Crystal Structure of the Leishmania Major Peroxidase-Cytochrome C Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0006979biological_processresponse to oxidative stress
A0020037molecular_functionheme binding
A0034599biological_processcellular response to oxidative stress
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0006122biological_processmitochondrial electron transport, ubiquinol to cytochrome c
B0006123biological_processmitochondrial electron transport, cytochrome c to oxygen
B0009055molecular_functionelectron transfer activity
B0020037molecular_functionheme binding
B0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE HEM A 401
ChainResidue
APRO60
AHIS198
APHE201
ASER202
ATRP208
ASER252
AHOH501
AHOH512
AHOH561
AHOH663
ATRP67
APRO162
ALEU188
AALA191
AHIS192
AGLY195
AGLU196
ACYS197

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K A 402
ChainResidue
ATHR193
ATHR209
AASP211
AGLY214
AASP216
ASER218
AHOH569

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 403
ChainResidue
AGLU69
ASER72
AGLY80
ASER81
ASER86
AGLU92

site_idAC4
Number of Residues22
DetailsBINDING SITE FOR RESIDUE HEC B 201
ChainResidue
BARG24
BALA25
BCYS28
BHIS29
BVAL39
BILE46
BSER51
BGLY52
BVAL54
BTYR59
BSER60
BASN63
BTRP70
BLEU75
BLEU79
BTHR89
BLYS90
BMET91
BSER92
BPHE93
BILE96
BHOH302

Functional Information from PROSITE/UniProt
site_idPS00436
Number of Residues12
DetailsPEROXIDASE_2 Peroxidases active site signature. GPslIRLaWHEA
ChainResidueDetails
AGLY59-ALA70

226707

PDB entries from 2024-10-30

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