Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD A 401 |
| Chain | Residue |
| A | GLY12 |
| A | ASN51 |
| A | GLY81 |
| A | ASP82 |
| A | ILE83 |
| A | ALA110 |
| A | THR111 |
| A | GLY112 |
| A | CYS137 |
| A | GLY276 |
| A | ASP277 |
| A | GLY14 |
| A | ARG284 |
| A | GLN285 |
| A | ILE286 |
| A | ALA289 |
| A | HOH501 |
| A | HOH503 |
| A | HOH504 |
| A | HOH511 |
| A | HOH520 |
| A | HOH531 |
| A | PRO15 |
| A | HOH536 |
| A | HOH558 |
| A | HOH575 |
| A | HOH596 |
| A | ALA16 |
| A | GLU35 |
| A | ARG36 |
| A | GLY41 |
| A | GLN42 |
| A | THR46 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | GLU159 |
| A | PHE162 |
| B | GLN298 |
| B | GLU302 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 403 |
| Chain | Residue |
| A | GLN298 |
| A | GLU302 |
| A | HOH623 |
| B | GLU159 |
| B | PHE162 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 404 |
| Chain | Residue |
| A | ILE4 |
| A | ASP7 |
| A | LYS30 |
| A | LYS105 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 405 |
| Chain | Residue |
| A | GLN79 |
| A | TYR80 |
| A | HOH540 |
| B | LYS72 |
| B | HOH558 |
| site_id | AC6 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD B 401 |
| Chain | Residue |
| B | GLY12 |
| B | GLY14 |
| B | PRO15 |
| B | ALA16 |
| B | GLU35 |
| B | ARG36 |
| B | GLY41 |
| B | GLN42 |
| B | THR46 |
| B | ASN51 |
| B | GLY81 |
| B | ASP82 |
| B | ILE83 |
| B | ALA110 |
| B | THR111 |
| B | GLY112 |
| B | CYS137 |
| B | GLY276 |
| B | ASP277 |
| B | ARG284 |
| B | GLN285 |
| B | ILE286 |
| B | ALA289 |
| B | HOH501 |
| B | HOH502 |
| B | HOH503 |
| B | HOH509 |
| B | HOH512 |
| B | HOH516 |
| B | HOH548 |
| B | HOH549 |
| B | HOH569 |
| B | HOH604 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE NAP B 402 |
| Chain | Residue |
| B | HOH582 |
| B | HOH592 |
| B | HOH689 |
| B | HOH716 |
| B | HOH745 |
| B | HOH773 |
| B | HOH790 |
| B | ILE118 |
| B | GLY152 |
| B | GLY153 |
| B | ASP154 |
| B | SER155 |
| B | GLU158 |
| B | ARG175 |
| B | ARG176 |
| B | ARG180 |
| B | GLN182 |
| B | TYR237 |
| B | ILE238 |
| B | HOH519 |
| B | HOH524 |
| B | HOH542 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE EPE B 403 |
| Chain | Residue |
| A | GLU226 |
| B | ASP177 |
| B | TRP199 |
| B | LYS222 |
| B | THR253 |
| B | ASN254 |
| B | ASP255 |
| B | HOH584 |
| B | HOH650 |
| B | HOH657 |
| B | HOH694 |
| B | HOH717 |
| B | HOH741 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL B 404 |
| Chain | Residue |
| A | LYS72 |
| B | GLN79 |
| B | TYR80 |
| B | HOH533 |
| B | HOH585 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CavCDGaf..FknkrLfVIGGGD |
| Chain | Residue | Details |
| A | CYS134-ASP154 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU35 | |
| A | ASP277 | |
| B | GLU35 | |
| B | ASP277 | |
