4GB1

Synthesis and Evaluation of Novel 3-C-alkylated-Neu5Ac2en Derivatives as Probes of Influenza Virus Sialidase 150-loop flexibility

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004308	molecular_function	exo-alpha-sialidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0016020	cellular_component	membrane
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASP151

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	TYR411

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ARG118
A	ARG152
A	GLU278
A	ARG294
A	ASP295
A	GLY299
A	ASP326
A	ARG376

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site_id	SWS_FT_FI4
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04071

Chain	Residue	Details
A	ASN86
A	ASN146
A	ASN407

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