Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GAM

Complex structure of Methane monooxygenase hydroxylase and regulatory subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005515	molecular_function	protein binding
A	0006730	biological_process	one-carbon metabolic process
A	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0005515	molecular_function	protein binding
B	0006730	biological_process	one-carbon metabolic process
B	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
B	0016491	molecular_function	oxidoreductase activity
B	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
C	0004497	molecular_function	monooxygenase activity
C	0006730	biological_process	one-carbon metabolic process
C	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
C	0015947	biological_process	methane metabolic process
C	0016491	molecular_function	oxidoreductase activity
D	0004497	molecular_function	monooxygenase activity
D	0016491	molecular_function	oxidoreductase activity
F	0004497	molecular_function	monooxygenase activity
F	0005515	molecular_function	protein binding
F	0006730	biological_process	one-carbon metabolic process
F	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
G	0004497	molecular_function	monooxygenase activity
G	0005515	molecular_function	protein binding
G	0006730	biological_process	one-carbon metabolic process
G	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
G	0016491	molecular_function	oxidoreductase activity
G	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
H	0004497	molecular_function	monooxygenase activity
H	0006730	biological_process	one-carbon metabolic process
H	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
H	0015947	biological_process	methane metabolic process
H	0016491	molecular_function	oxidoreductase activity
I	0004497	molecular_function	monooxygenase activity
I	0016491	molecular_function	oxidoreductase activity
K	0004497	molecular_function	monooxygenase activity
K	0005515	molecular_function	protein binding
K	0006730	biological_process	one-carbon metabolic process
K	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
L	0004497	molecular_function	monooxygenase activity
L	0005515	molecular_function	protein binding
L	0006730	biological_process	one-carbon metabolic process
L	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
L	0016491	molecular_function	oxidoreductase activity
L	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
M	0004497	molecular_function	monooxygenase activity
M	0006730	biological_process	one-carbon metabolic process
M	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
M	0015947	biological_process	methane metabolic process
M	0016491	molecular_function	oxidoreductase activity
N	0004497	molecular_function	monooxygenase activity
N	0016491	molecular_function	oxidoreductase activity
P	0004497	molecular_function	monooxygenase activity
P	0005515	molecular_function	protein binding
P	0006730	biological_process	one-carbon metabolic process
P	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
P	0016491	molecular_function	oxidoreductase activity
P	0046872	molecular_function	metal ion binding
Q	0004497	molecular_function	monooxygenase activity
Q	0005515	molecular_function	protein binding
Q	0006730	biological_process	one-carbon metabolic process
Q	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
Q	0016491	molecular_function	oxidoreductase activity
Q	0016709	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
R	0004497	molecular_function	monooxygenase activity
R	0006730	biological_process	one-carbon metabolic process
R	0015049	molecular_function	methane monooxygenase [NAD(P)H] activity
R	0015947	biological_process	methane metabolic process
R	0016491	molecular_function	oxidoreductase activity
S	0004497	molecular_function	monooxygenase activity
S	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE A 601

Chain	Residue
A	GLU114
A	GLU144
A	GLU209
A	GLU243
A	HIS246
A	FE602

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 602

Chain	Residue
A	GLU243
A	FE601
A	GLU114
A	GLU144
A	HIS147

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE F 601

Chain	Residue
F	GLU114
F	GLU144
F	HIS147
F	GLU243
F	FE602

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE F 602

Chain	Residue
F	GLU144
F	GLU209
F	GLU243
F	HIS246
F	FE601

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE K 601

Chain	Residue
K	GLU114
K	GLU144
K	HIS147
K	GLU243
K	FE602

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE K 602

Chain	Residue
K	GLU144
K	GLU209
K	GLU243
K	HIS246
K	FE601

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE P 601

Chain	Residue
P	GLU114
P	GLU144
P	HIS147
P	GLU243
P	FE602

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE P 602

Chain	Residue
P	GLU144
P	GLU209
P	GLU243
P	HIS246
P	FE601

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)