4G74
Crystal structure of NDH with Quinone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| A | 0015980 | biological_process | energy derivation by oxidation of organic compounds |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| A | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
| B | 0003954 | molecular_function | NADH dehydrogenase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| B | 0015980 | biological_process | energy derivation by oxidation of organic compounds |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| B | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UQ5 A 601 |
| Chain | Residue |
| A | HIS397 |
| A | SER484 |
| A | MET485 |
| A | LEU487 |
| A | UQ5602 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE UQ5 A 602 |
| Chain | Residue |
| A | ILE459 |
| A | PHE466 |
| A | MET485 |
| A | UQ5601 |
| A | FAD607 |
| A | TRP63 |
| A | PRO92 |
| A | LEU444 |
| A | LEU447 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRT A 603 |
| Chain | Residue |
| A | PHE497 |
| A | ILE500 |
| A | TRT604 |
| B | PHE504 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TRT A 604 |
| Chain | Residue |
| A | PHE504 |
| A | PHE505 |
| A | TRT603 |
| B | LYS117 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE TRT A 605 |
| Chain | Residue |
| A | ARG479 |
| A | LEU483 |
| A | PHE496 |
| A | TRP499 |
| A | ALA503 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 606 |
| Chain | Residue |
| A | LEU502 |
| A | PHE505 |
| site_id | AC7 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 607 |
| Chain | Residue |
| A | GLY60 |
| A | SER61 |
| A | GLY62 |
| A | TRP63 |
| A | GLY64 |
| A | ILE82 |
| A | SER83 |
| A | PRO84 |
| A | ARG85 |
| A | THR91 |
| A | PRO92 |
| A | GLU128 |
| A | ALA129 |
| A | ALA175 |
| A | VAL176 |
| A | GLY177 |
| A | LEU195 |
| A | THR239 |
| A | ARG344 |
| A | GLY382 |
| A | ASP383 |
| A | PRO391 |
| A | THR392 |
| A | ALA393 |
| A | GLN394 |
| A | ALA396 |
| A | TYR482 |
| A | UQ5602 |
| A | MG608 |
| A | MG609 |
| A | MG610 |
| A | MG611 |
| A | HOH703 |
| A | HOH704 |
| A | HOH743 |
| A | HOH754 |
| A | HOH844 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG A 608 |
| Chain | Residue |
| A | ALA175 |
| A | VAL176 |
| A | GLY177 |
| A | ILE381 |
| A | GLY382 |
| A | ASP383 |
| A | ASN384 |
| A | FAD607 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 609 |
| Chain | Residue |
| A | GLY62 |
| A | GLY64 |
| A | ALA65 |
| A | ALA175 |
| A | FAD607 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 610 |
| Chain | Residue |
| A | ARG85 |
| A | THR91 |
| A | FAD607 |
| A | HOH704 |
| A | HOH716 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 611 |
| Chain | Residue |
| A | GLY177 |
| A | ALA178 |
| A | LYS196 |
| A | FAD607 |
| A | HOH732 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | GLY333 |
| B | HOH707 |
| B | HOH722 |
| B | HOH761 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE UQ5 B 602 |
| Chain | Residue |
| B | MET485 |
| B | UQ5603 |
| B | FAD606 |
| B | HOH748 |
| B | TRP63 |
| B | ALA393 |
| B | GLN394 |
| B | LEU444 |
| B | GLY445 |
| B | LEU447 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE UQ5 B 603 |
| Chain | Residue |
| B | HIS397 |
| B | SER484 |
| B | MET485 |
| B | LEU487 |
| B | ARG492 |
| B | UQ5602 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRT B 604 |
| Chain | Residue |
| B | ARG479 |
| B | ILE480 |
| B | LEU483 |
| B | PHE496 |
| B | TRP499 |
| B | ALA503 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 605 |
| Chain | Residue |
| B | ASP254 |
| B | LEU502 |
| B | PHE505 |
| B | ARG507 |
| B | HOH774 |
| B | HOH805 |
| site_id | BC8 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD B 606 |
| Chain | Residue |
| B | GLY60 |
| B | SER61 |
| B | GLY62 |
| B | TRP63 |
| B | GLY64 |
| B | ILE82 |
| B | SER83 |
| B | PRO84 |
| B | ARG85 |
| B | THR91 |
| B | PRO92 |
| B | GLU128 |
| B | ALA129 |
| B | ALA175 |
| B | VAL176 |
| B | GLY177 |
| B | LEU195 |
| B | THR239 |
| B | ARG344 |
| B | GLY382 |
| B | ASP383 |
| B | PRO391 |
| B | THR392 |
| B | ALA393 |
| B | GLN394 |
| B | ALA396 |
| B | TYR482 |
| B | UQ5602 |
| B | MG607 |
| B | MG608 |
| B | MG609 |
| B | MG610 |
| B | HOH703 |
| B | HOH708 |
| B | HOH771 |
| B | HOH830 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 607 |
| Chain | Residue |
| B | ALA175 |
| B | VAL176 |
| B | GLY177 |
| B | ILE381 |
| B | GLY382 |
| B | ASP383 |
| B | ASN384 |
| B | FAD606 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 608 |
| Chain | Residue |
| B | GLY62 |
| B | GLY64 |
| B | ALA65 |
| B | ALA175 |
| B | FAD606 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 609 |
| Chain | Residue |
| B | GLY62 |
| B | ARG85 |
| B | LEU89 |
| B | FAD606 |
| B | HOH708 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 610 |
| Chain | Residue |
| B | GLY177 |
| B | ALA178 |
| B | LYS196 |
| B | ASP383 |
| B | FAD606 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
