4G73
Crystal structure of NDH with NADH and Quinone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006116 | biological_process | NADH oxidation |
| A | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| A | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0003954 | molecular_function | NADH dehydrogenase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006116 | biological_process | NADH oxidation |
| B | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| B | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UQ5 A 601 |
| Chain | Residue |
| A | PHE504 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 603 |
| Chain | Residue |
| A | PRO48 |
| A | GLN49 |
| A | SER51 |
| A | LYS53 |
| A | ASN55 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE UQ5 A 604 |
| Chain | Residue |
| A | HIS397 |
| A | LEU444 |
| A | ALA446 |
| A | LEU447 |
| A | ILE459 |
| A | MET485 |
| A | FAD605 |
| A | TRP63 |
| A | ALA393 |
| A | GLN394 |
| site_id | AC4 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 605 |
| Chain | Residue |
| A | GLY60 |
| A | SER61 |
| A | GLY62 |
| A | TRP63 |
| A | GLY64 |
| A | ILE82 |
| A | SER83 |
| A | PRO84 |
| A | ARG85 |
| A | THR91 |
| A | PRO92 |
| A | PRO95 |
| A | GLU128 |
| A | ALA129 |
| A | ALA175 |
| A | VAL176 |
| A | GLY177 |
| A | LEU195 |
| A | THR239 |
| A | ARG344 |
| A | GLY382 |
| A | ASP383 |
| A | PRO391 |
| A | THR392 |
| A | ALA393 |
| A | GLN394 |
| A | ALA396 |
| A | TYR482 |
| A | UQ5604 |
| A | MG606 |
| A | MG607 |
| A | MG608 |
| A | MG609 |
| A | NAI610 |
| A | HOH702 |
| A | HOH715 |
| A | HOH760 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG A 606 |
| Chain | Residue |
| A | ALA175 |
| A | VAL176 |
| A | GLY177 |
| A | ILE381 |
| A | GLY382 |
| A | ASP383 |
| A | ASN384 |
| A | FAD605 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 607 |
| Chain | Residue |
| A | GLY62 |
| A | GLY64 |
| A | ALA65 |
| A | ALA175 |
| A | FAD605 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 608 |
| Chain | Residue |
| A | GLY62 |
| A | ARG85 |
| A | LEU89 |
| A | FAD605 |
| A | HOH702 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 609 |
| Chain | Residue |
| A | GLY177 |
| A | ALA178 |
| A | LYS196 |
| A | ASP383 |
| A | FAD605 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAI A 610 |
| Chain | Residue |
| A | VAL234 |
| A | GLY235 |
| A | PRO238 |
| A | THR239 |
| A | GLU242 |
| A | GLU272 |
| A | ALA273 |
| A | LEU274 |
| A | THR304 |
| A | ALA305 |
| A | VAL306 |
| A | ALA338 |
| A | THR339 |
| A | PRO391 |
| A | LEU447 |
| A | TYR482 |
| A | FAD605 |
| A | HOH706 |
| A | HOH869 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | GLY333 |
| B | HOH720 |
| B | HOH847 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 602 |
| Chain | Residue |
| B | LYS118 |
| B | HOH721 |
| B | LEU116 |
| site_id | BC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAI B 603 |
| Chain | Residue |
| B | VAL234 |
| B | GLY235 |
| B | GLY236 |
| B | GLY237 |
| B | PRO238 |
| B | THR239 |
| B | GLU242 |
| B | VAL271 |
| B | GLU272 |
| B | ALA273 |
| B | LEU274 |
| B | THR304 |
| B | ALA305 |
| B | VAL306 |
| B | ALA338 |
| B | THR339 |
| B | GLY340 |
| B | PRO391 |
| B | LEU447 |
| B | TYR482 |
| B | FAD606 |
| B | HOH845 |
| B | HOH877 |
| B | HOH889 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UQ5 B 604 |
| Chain | Residue |
| B | ALA503 |
| B | PHE504 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE UQ5 B 605 |
| Chain | Residue |
| B | TRP63 |
| B | ALA393 |
| B | GLN394 |
| B | LEU444 |
| B | LEU447 |
| B | ILE459 |
| B | MET485 |
| B | FAD606 |
| site_id | BC6 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD B 606 |
| Chain | Residue |
| B | GLY60 |
| B | SER61 |
| B | GLY62 |
| B | TRP63 |
| B | GLY64 |
| B | ILE82 |
| B | SER83 |
| B | PRO84 |
| B | ARG85 |
| B | THR91 |
| B | PRO92 |
| B | GLU128 |
| B | ALA129 |
| B | ALA175 |
| B | VAL176 |
| B | GLY177 |
| B | LEU195 |
| B | LYS196 |
| B | THR239 |
| B | ARG344 |
| B | GLY382 |
| B | ASP383 |
| B | PRO391 |
| B | THR392 |
| B | ALA393 |
| B | GLN394 |
| B | ALA396 |
| B | TYR482 |
| B | NAI603 |
| B | UQ5605 |
| B | MG607 |
| B | MG608 |
| B | MG609 |
| B | MG610 |
| B | HOH704 |
| B | HOH723 |
| B | HOH755 |
| B | HOH803 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 607 |
| Chain | Residue |
| B | ALA175 |
| B | VAL176 |
| B | GLY177 |
| B | ILE381 |
| B | GLY382 |
| B | ASP383 |
| B | ASN384 |
| B | FAD606 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 608 |
| Chain | Residue |
| B | GLY62 |
| B | TRP63 |
| B | GLY64 |
| B | ALA65 |
| B | ALA175 |
| B | FAD606 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 609 |
| Chain | Residue |
| B | GLY62 |
| B | ARG85 |
| B | LEU89 |
| B | FAD606 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 610 |
| Chain | Residue |
| B | ALA178 |
| B | LYS196 |
| B | ASP383 |
| B | FAD606 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN55 | |
| A | LEU229 | |
| B | ASN55 | |
| B | LEU229 |
