4G6H
Crystal structure of NDH with NADH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003954 | molecular_function | NADH dehydrogenase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| A | 0015980 | biological_process | energy derivation by oxidation of organic compounds |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043065 | biological_process | positive regulation of apoptotic process |
| A | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| A | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
| B | 0003954 | molecular_function | NADH dehydrogenase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
| B | 0015980 | biological_process | energy derivation by oxidation of organic compounds |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043065 | biological_process | positive regulation of apoptotic process |
| B | 0050136 | molecular_function | NADH dehydrogenase (quinone) (non-electrogenic) activity |
| B | 0120555 | molecular_function | NADH dehydrogenase (ubiquinone) (non-electrogenic) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD A 601 |
| Chain | Residue |
| A | GLY60 |
| A | THR91 |
| A | PRO92 |
| A | GLU128 |
| A | ALA129 |
| A | ALA175 |
| A | VAL176 |
| A | GLY177 |
| A | LEU195 |
| A | THR239 |
| A | ARG344 |
| A | SER61 |
| A | GLY382 |
| A | ASP383 |
| A | PRO391 |
| A | THR392 |
| A | ALA393 |
| A | GLN394 |
| A | ALA396 |
| A | TYR482 |
| A | NAI602 |
| A | HOH701 |
| A | GLY62 |
| A | HOH706 |
| A | HOH707 |
| A | HOH709 |
| A | HOH713 |
| A | HOH730 |
| A | HOH731 |
| A | HOH733 |
| A | HOH740 |
| A | HOH768 |
| A | HOH824 |
| A | TRP63 |
| A | GLY64 |
| A | ILE82 |
| A | SER83 |
| A | PRO84 |
| A | ARG85 |
| site_id | AC2 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAI A 602 |
| Chain | Residue |
| A | VAL234 |
| A | GLY235 |
| A | GLY237 |
| A | PRO238 |
| A | THR239 |
| A | GLU242 |
| A | GLU272 |
| A | ALA273 |
| A | LEU274 |
| A | THR304 |
| A | ALA305 |
| A | VAL306 |
| A | ALA338 |
| A | THR339 |
| A | GLY340 |
| A | ASN341 |
| A | PRO391 |
| A | THR392 |
| A | FAD601 |
| A | HOH701 |
| A | HOH723 |
| A | HOH761 |
| A | HOH770 |
| A | HOH774 |
| A | HOH809 |
| A | HOH815 |
| A | HOH827 |
| A | HOH863 |
| A | HOH921 |
| A | HOH956 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 603 |
| Chain | Residue |
| A | THR189 |
| A | GLY192 |
| A | HOH757 |
| A | HOH765 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 604 |
| Chain | Residue |
| A | VAL266 |
| A | SER297 |
| A | HOH714 |
| A | HOH736 |
| A | HOH856 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 605 |
| Chain | Residue |
| A | PRO48 |
| A | GLN49 |
| A | SER51 |
| A | LYS53 |
| A | ASN55 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | GLU203 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 602 |
| Chain | Residue |
| B | GLY333 |
| B | HOH727 |
| B | HOH728 |
| B | HOH818 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 603 |
| Chain | Residue |
| B | PRO134 |
| B | ASN137 |
| B | TYR169 |
| B | ASN377 |
| B | ILE378 |
| B | HOH908 |
| site_id | AC9 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAI B 604 |
| Chain | Residue |
| B | VAL271 |
| B | GLU272 |
| B | ALA273 |
| B | LEU274 |
| B | THR304 |
| B | ALA305 |
| B | VAL306 |
| B | THR339 |
| B | GLY340 |
| B | ASN341 |
| B | PRO391 |
| B | THR392 |
| B | FAD605 |
| B | HOH701 |
| B | HOH704 |
| B | HOH751 |
| B | HOH777 |
| B | HOH794 |
| B | HOH817 |
| B | HOH831 |
| B | HOH868 |
| B | HOH877 |
| B | HOH888 |
| B | VAL234 |
| B | GLY235 |
| B | PRO238 |
| B | THR239 |
| B | GLU242 |
| site_id | BC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 605 |
| Chain | Residue |
| B | GLY60 |
| B | SER61 |
| B | GLY62 |
| B | TRP63 |
| B | GLY64 |
| B | ILE82 |
| B | SER83 |
| B | PRO84 |
| B | ARG85 |
| B | THR91 |
| B | PRO92 |
| B | GLU128 |
| B | ALA129 |
| B | ALA175 |
| B | VAL176 |
| B | GLY177 |
| B | THR239 |
| B | ARG344 |
| B | GLY382 |
| B | ASP383 |
| B | PRO391 |
| B | THR392 |
| B | ALA393 |
| B | GLN394 |
| B | ALA396 |
| B | TYR482 |
| B | NAI604 |
| B | HOH701 |
| B | HOH703 |
| B | HOH720 |
| B | HOH726 |
| B | HOH730 |
| B | HOH735 |
| B | HOH738 |
| B | HOH741 |
| B | HOH784 |
| B | HOH801 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
