4G5H

Crystal structure of capsular polysaccharide synthesizing enzyme CapE from Staphylococcus aureus in complex with by-product

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003978	molecular_function	UDP-glucose 4-epimerase activity
A	0009103	biological_process	lipopolysaccharide biosynthetic process
A	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE NAP A 401

Chain	Residue
A	GLY11
A	LYS41
A	ASP60
A	VAL61
A	ALA80
A	ALA81
A	ALA82
A	LYS84
A	LEU122
A	SER123
A	LYS138
A	THR13
A	TYR164
A	GLY165
A	SER170
A	UD7402
A	FMT417
A	HOH503
A	HOH554
A	HOH558
A	HOH573
A	HOH579
A	GLY14
A	HOH583
A	HOH620
A	SER15
A	PHE16
A	SER36
A	ARG37
A	ASP38
A	LYS40

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE UD7 A 402

Chain	Residue
A	LYS84
A	GLN85
A	VAL86
A	LYS126
A	ASN166
A	SER173
A	VAL174
A	LEU177
A	THR189
A	ILE190
A	THR191
A	MET195
A	VAL231
A	ARG254
A	GLU257
A	TYR293
A	NAP401
A	HOH537
A	HOH598
A	HOH599
A	HOH603
A	HOH604

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE UD7 A 403

Chain	Residue
A	LYS214
A	GLU217
A	TYR269
A	SER304
A	TYR305
A	GLU306
A	TYR307
A	ASN311
A	HOH624

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 404

Chain	Residue
A	ARG33
A	ARG72
A	ASP73
A	ASN151
A	HOH571
A	HOH600

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 405

Chain	Residue
A	ARG62
A	ILE102
A	ASN106
A	FMT412
A	HOH549

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 406

Chain	Residue
A	GLU90
A	GLU267
A	ASP284
A	TYR293
A	HOH557
A	HOH607
A	HOH608

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 407

Chain	Residue
A	ARG46
A	ASN289
A	TYR290
A	SER291
A	HOH634

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FMT A 408

Chain	Residue
A	TYR129
A	LYS258
A	LYS259
A	ARG266
A	FMT409
A	HOH611

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 409

Chain	Residue
A	LYS259
A	ALA260
A	FMT408
A	HOH610

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FMT A 410

Chain	Residue
A	GLN224
A	LYS225
A	ALA226
A	PRO227
A	LYS323
A	ARG-4
A	LEU199
A	MET200
A	ASP204

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 411

Chain	Residue
A	PHE92
A	PRO93
A	VAL94
A	GLU95
A	HOH509
A	HOH529
A	HOH622

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 412

Chain	Residue
A	SER64
A	ASN106
A	GLN109
A	FMT405
A	HOH511

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 413

Chain	Residue
A	GLU68
A	SER110
A	HIS113
A	GLN114

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 414

Chain	Residue
A	GLU217
A	ARG286
A	HOH524
A	HOH532
A	HOH591

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FMT A 415

Chain	Residue
A	ARG150
A	ARG286
A	NA418
A	HOH560
A	HOH562

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FMT A 416

Chain	Residue
A	ASP310
A	ASN311
A	THR312
A	ILE314

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FMT A 417

Chain	Residue
A	ARG37
A	ASP60
A	ASP60
A	ARG62
A	NAP401
A	HOH583
A	HOH636

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA A 418

Chain	Residue
A	SER149
A	ARG150
A	ILE152
A	FMT415
A	HOH560
A	HOH561
A	HOH577

---