4G3M

Complex Structure of Bacillus subtilis RibG: The Deamination Process in Riboflavin Biosynthesis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
A	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
A	0009231	biological_process	riboflavin biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
B	0003824	molecular_function	catalytic activity
B	0008270	molecular_function	zinc ion binding
B	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
B	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
B	0009231	biological_process	riboflavin biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
C	0003824	molecular_function	catalytic activity
C	0008270	molecular_function	zinc ion binding
C	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
C	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
C	0009231	biological_process	riboflavin biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
D	0003824	molecular_function	catalytic activity
D	0008270	molecular_function	zinc ion binding
D	0008703	molecular_function	5-amino-6-(5-phosphoribosylamino)uracil reductase activity
D	0008835	molecular_function	diaminohydroxyphosphoribosylaminopyrimidine deaminase activity
D	0009231	biological_process	riboflavin biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS49
A	GLU51
A	CYS74
A	CYS83

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AI9 A 402

Chain	Residue
A	ARG176
A	ARG183
A	ASP199
A	PRO201
A	SER202
A	LEU203
A	THR204
A	ARG206
A	GLU290
A	HOH511
A	HOH546
A	HOH603
A	LYS151
A	ALA153
A	SER167
A	ILE170
A	THR171

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	HIS49
B	CYS74
B	CYS83
B	AOF402

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AOF B 402

Chain	Residue
B	ASN23
B	VAL26
B	HIS42
B	HIS49
B	ALA50
B	GLU51
B	CYS74
B	HIS76
B	LYS79
B	THR80
B	CYS83
B	ASP101
B	ASN103
B	PHE137
B	ZN401
B	HOH503
B	HOH533

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AI9 B 403

Chain	Residue
B	LYS151
B	ALA153
B	SER167
B	ILE170
B	THR171
B	ARG176
B	ARG183
B	ASP199
B	PRO201
B	SER202
B	LEU203
B	ARG206
B	HOH568

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 401

Chain	Residue
C	HIS49
C	CYS74
C	CYS83
C	AOF402

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AOF C 402

Chain	Residue
C	ASN23
C	PRO24
C	VAL26
C	HIS42
C	HIS49
C	ALA50
C	GLU51
C	CYS74
C	GLY78
C	LYS79
C	THR80
C	ASP101
C	PHE137
C	ZN401
C	HOH550
C	HOH561

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE AI9 C 403

Chain	Residue
C	LYS151
C	ALA153
C	SER167
C	TRP169
C	ILE170
C	THR171
C	ARG176
C	ARG183
C	ASP199
C	PRO201
C	SER202
C	LEU203
C	ARG206
C	GLU290
C	HOH506
C	HOH549

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 401

Chain	Residue
D	HIS49
D	CYS74
D	CYS83
D	AOF402

---

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE AOF D 402

Chain	Residue
D	HIS49
D	ALA50
D	GLU51
D	CYS74
D	HIS76
D	GLY78
D	LYS79
D	THR80
D	CYS83
D	ASP101
D	PHE137
D	ZN401
D	HOH530
D	HOH549
D	ASN23
D	PRO24
D	VAL26
D	HIS42

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AI9 D 403

Chain	Residue
D	LYS151
D	ALA153
D	ILE170
D	THR171
D	ARG176
D	ARG183
D	ASP199
D	PRO201
D	SER202
D	LEU203
D	ARG206
D	GLU290

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEvhAIhmagahaegadiyvtle................PCshygktppCaelI

Chain	Residue	Details
A	HIS49-ILE87

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	484
Details	Domain: {"description":"CMP/dCMP-type deaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	572
Details	Region: {"description":"Deaminase"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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