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4G2Y

Crystal structure of PDE5A complexed with its inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004114molecular_function3',5'-cyclic-nucleotide phosphodiesterase activity
A0007165biological_processsignal transduction
A0008081molecular_functionphosphoric diester hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PEG A 901
ChainResidue
AHIS657
AGLU682
AASP724
AHOH1020
AHOH1055

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ZN A 902
ChainResidue
AMG903
AHOH1009
AHOH1065
AHIS617
AHIS653
AASP654
AASP764

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 903
ChainResidue
AASP654
AZN902
AHOH1001
AHOH1004
AHOH1055
AHOH1057
AHOH1065

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE NI5 A 904
ChainResidue
ATYR612
ALEU672
ALEU725
AALA779
APHE786
AGLN817
APHE820
AILE824

Functional Information from PROSITE/UniProt
site_idPS00126
Number of Residues12
DetailsPDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY
ChainResidueDetails
AHIS653-TYR664

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083
ChainResidueDetails
AHIS613

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1T9R, ECO:0007744|PDB:1T9S, ECO:0007744|PDB:1TBF
ChainResidueDetails
AHIS617
AHIS653
AASP654
AASP764

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:12955149
ChainResidueDetails
AGLN817

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PDB entries from 2024-09-11

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