4G2N
Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0051287 | molecular_function | NAD binding |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0051287 | molecular_function | NAD binding |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0051287 | molecular_function | NAD binding |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 401 |
| Chain | Residue |
| A | ARG153 |
| A | HOH697 |
| A | ASP208 |
| A | PRO233 |
| A | GLU234 |
| A | GLY235 |
| A | ALA236 |
| A | HOH558 |
| A | HOH603 |
| A | HOH671 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 402 |
| Chain | Residue |
| A | TYR126 |
| A | ASP129 |
| A | ARG130 |
| A | HOH530 |
| A | HOH614 |
| C | TYR126 |
| C | ASP129 |
| C | ARG130 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 401 |
| Chain | Residue |
| B | ARG153 |
| B | ASP208 |
| B | GLU234 |
| B | GLY235 |
| B | ALA236 |
| B | HOH597 |
| B | HOH611 |
| B | HOH654 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 402 |
| Chain | Residue |
| B | GLU297 |
| D | GLY149 |
| D | ARG153 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 501 |
| Chain | Residue |
| C | MSE148 |
| C | ARG153 |
| C | ASP208 |
| C | PRO233 |
| C | GLU234 |
| C | GLY235 |
| C | HOH757 |
| C | HOH791 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 401 |
| Chain | Residue |
| B | TYR126 |
| B | ASP129 |
| B | ARG130 |
| D | TYR126 |
| D | ASP129 |
| D | ARG130 |
| D | HOH536 |
| D | HOH584 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 402 |
| Chain | Residue |
| D | ARG153 |
| D | ASP208 |
| D | PRO233 |
| D | GLU234 |
| D | GLY235 |
| D | HOH625 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL D 403 |
| Chain | Residue |
| D | ASP104 |
| D | VAL105 |
| D | LEU106 |
| D | SER107 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIFGmGRIGraiatrargfgla.IHyHN |
| Chain | Residue | Details |
| A | LEU155-ASN182 |
