4G2N

Crystal structure of putative D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding from Polaromonas sp. JS6 66

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016618	molecular_function	hydroxypyruvate reductase [NAD(P)H] activity
A	0030267	molecular_function	glyoxylate reductase (NADPH) activity
A	0051287	molecular_function	NAD binding
B	0005829	cellular_component	cytosol
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0016618	molecular_function	hydroxypyruvate reductase [NAD(P)H] activity
B	0030267	molecular_function	glyoxylate reductase (NADPH) activity
B	0051287	molecular_function	NAD binding
C	0005829	cellular_component	cytosol
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0016618	molecular_function	hydroxypyruvate reductase [NAD(P)H] activity
C	0030267	molecular_function	glyoxylate reductase (NADPH) activity
C	0051287	molecular_function	NAD binding
D	0005829	cellular_component	cytosol
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0016618	molecular_function	hydroxypyruvate reductase [NAD(P)H] activity
D	0030267	molecular_function	glyoxylate reductase (NADPH) activity
D	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	ARG153
A	HOH697
A	ASP208
A	PRO233
A	GLU234
A	GLY235
A	ALA236
A	HOH558
A	HOH603
A	HOH671

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	TYR126
A	ASP129
A	ARG130
A	HOH530
A	HOH614
C	TYR126
C	ASP129
C	ARG130

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 401

Chain	Residue
B	ARG153
B	ASP208
B	GLU234
B	GLY235
B	ALA236
B	HOH597
B	HOH611
B	HOH654

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	GLU297
D	GLY149
D	ARG153

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site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 501

Chain	Residue
C	MSE148
C	ARG153
C	ASP208
C	PRO233
C	GLU234
C	GLY235
C	HOH757
C	HOH791

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 401

Chain	Residue
B	TYR126
B	ASP129
B	ARG130
D	TYR126
D	ASP129
D	ARG130
D	HOH536
D	HOH584

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL D 402

Chain	Residue
D	ARG153
D	ASP208
D	PRO233
D	GLU234
D	GLY235
D	HOH625

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 403

Chain	Residue
D	ASP104
D	VAL105
D	LEU106
D	SER107

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Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIFGmGRIGraiatrargfgla.IHyHN

Chain	Residue	Details
A	LEU155-ASN182

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