4G1C
Human SIRT5 bound to Succ-IDH2 and Carba-NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | CYS166 |
| A | CYS169 |
| A | CYS207 |
| A | CYS212 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE CNA A 402 |
| Chain | Residue |
| A | PRO68 |
| A | THR69 |
| A | PHE70 |
| A | ARG71 |
| A | GLN140 |
| A | ASN141 |
| A | ILE142 |
| A | ASP143 |
| A | HIS158 |
| A | GLY249 |
| A | THR250 |
| A | SER251 |
| A | ASN275 |
| A | THR276 |
| A | GLU277 |
| A | PRO292 |
| A | CYS293 |
| A | HOH550 |
| A | HOH561 |
| A | HOH568 |
| D | SLL3 |
| A | ALA59 |
| A | GLY60 |
| A | ALA63 |
| A | GLU64 |
| A | VAL67 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 401 |
| Chain | Residue |
| B | CYS166 |
| B | CYS169 |
| B | CYS207 |
| B | CYS212 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:29180469 |
| Chain | Residue | Details |
| A | HIS158 | |
| B | HIS158 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:22767592, ECO:0000269|Ref.19 |
| Chain | Residue | Details |
| A | GLY58 | |
| B | CYS293 | |
| A | GLN140 | |
| A | GLY249 | |
| A | ASN275 | |
| A | CYS293 | |
| B | GLY58 | |
| B | GLN140 | |
| B | GLY249 | |
| B | ASN275 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
| Chain | Residue | Details |
| A | TYR102 | |
| B | CYS169 | |
| B | CYS207 | |
| B | CYS212 | |
| A | ARG105 | |
| A | CYS166 | |
| A | CYS169 | |
| A | CYS207 | |
| A | CYS212 | |
| B | TYR102 | |
| B | ARG105 | |
| B | CYS166 |
