Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006259 | biological_process | DNA metabolic process |
A | 0006265 | biological_process | DNA topological change |
B | 0003677 | molecular_function | DNA binding |
B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006259 | biological_process | DNA metabolic process |
B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
site_id | 1 |
Number of Residues | |
Details | |
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 1301 |
Chain | Residue |
A | ASP557 |
A | ASP559 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 1302 |
Chain | Residue |
A | ASN867 |
A | GLY868 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG B 1301 |
Chain | Residue |
B | ASP557 |
B | ASP559 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 1302 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE AKE D 101 |
Chain | Residue |
B | LYS505 |
B | LEU507 |
B | ASN520 |
B | GLU522 |
B | GLN778 |
B | MET782 |
D | DA12 |
D | DG13 |
D | DC14 |
E | DG7 |
E | DC8 |
F | DT9 |
B | ARG503 |
B | GLY504 |
site_id | AC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG D 102 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE AKE F 101 |
Chain | Residue |
A | ARG503 |
A | LYS505 |
A | ILE506 |
A | ASN520 |
A | GLU522 |
A | GLN778 |
A | MET782 |
C | DG7 |
C | DC8 |
D | DT9 |
F | DA12 |
F | DG13 |
F | DC14 |
site_id | AC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG F 102 |
Functional Information from PROSITE/UniProt
site_id | PS00177 |
Number of Residues | 9 |
Details | TOPOISOMERASE_II DNA topoisomerase II signature. LTEGDSAKS |
Chain | Residue | Details |
A | LEU475-SER483 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 234 |
Details | Domain: {"description":"Toprim","evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]} |
site_id | SWS_FT_FI2 |
Number of Residues | 18 |
Details | Region: {"description":"Interaction with DNA"} |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | Motif: {"description":"Nuclear export signal"} |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01384","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21778401","evidenceCode":"ECO:0000269"}]} |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]} |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21778401","evidenceCode":"ECO:0000269"}]} |
site_id | SWS_FT_FI7 |
Number of Residues | 12 |
Details | Site: {"description":"Interaction with DNA"} |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00995","evidenceCode":"ECO:0000255"}]} |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | Site: {"description":"Transition state stabilizer"} |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | Site: {"description":"Important for DNA bending; intercalates between base pairs of target DNA"} |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |