4G0K
Glutathionyl-hydroquinone reductase, YqjG, of E.coli complexed with GS-menadione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016672 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0004364 | molecular_function | glutathione transferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016672 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | ARG73 |
| A | LYS74 |
| A | GLU285 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | ASP276 |
| A | GLN279 |
| A | HIS321 |
| A | SO4406 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 403 |
| Chain | Residue |
| A | LYS261 |
| A | HIS262 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 404 |
| Chain | Residue |
| A | HIS262 |
| A | ASP266 |
| A | HOH560 |
| A | HOH577 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 405 |
| Chain | Residue |
| A | PRO103 |
| A | GLY104 |
| A | HOH537 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 406 |
| Chain | Residue |
| A | ARG228 |
| A | ASP324 |
| A | SO4402 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 407 |
| Chain | Residue |
| A | ASN288 |
| A | PHE289 |
| A | ASP290 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES A 408 |
| Chain | Residue |
| A | GLY168 |
| A | ASP169 |
| A | TYR170 |
| A | TYR229 |
| A | GLN234 |
| A | LEU235 |
| A | HOH542 |
| B | LYS52 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MES A 409 |
| Chain | Residue |
| A | SER202 |
| A | GLN203 |
| A | GLU204 |
| B | THR306 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES A 410 |
| Chain | Residue |
| A | TRP65 |
| A | ARG68 |
| A | GLU148 |
| A | ALA150 |
| A | GLY184 |
| A | TYR187 |
| A | ARG241 |
| A | 0VS411 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 0VS A 411 |
| Chain | Residue |
| A | CYS63 |
| A | TRP65 |
| A | TRP96 |
| A | ARG130 |
| A | THR132 |
| A | VAL133 |
| A | PRO134 |
| A | ASN147 |
| A | GLU148 |
| A | SER149 |
| A | MES410 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | ARG73 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 402 |
| Chain | Residue |
| B | TRP65 |
| B | ARG68 |
| B | GLU148 |
| B | ALA150 |
| B | TYR187 |
| B | ARG241 |
| B | 0VS410 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 403 |
| Chain | Residue |
| B | LYS261 |
| B | HIS262 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 404 |
| Chain | Residue |
| B | PRO103 |
| B | GLY104 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 405 |
| Chain | Residue |
| B | VAL287 |
| B | ASN288 |
| B | PHE289 |
| B | ASP290 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 406 |
| Chain | Residue |
| B | HIS262 |
| B | ASP266 |
| B | HOH549 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 407 |
| Chain | Residue |
| B | ARG228 |
| B | ASP324 |
| B | MES409 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 408 |
| Chain | Residue |
| B | SER202 |
| B | GLN203 |
| B | GLU204 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES B 409 |
| Chain | Residue |
| B | ASP169 |
| B | TYR170 |
| B | TYR229 |
| B | GLN234 |
| B | LEU235 |
| B | SO4407 |
| site_id | CC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 0VS B 410 |
| Chain | Residue |
| B | TRP65 |
| B | TRP96 |
| B | ARG130 |
| B | THR132 |
| B | VAL133 |
| B | PRO134 |
| B | ASN147 |
| B | GLU148 |
| B | SER149 |
| B | SO4402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:22955277 |
| Chain | Residue | Details |
| A | CYS63 | |
| B | CYS63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:22955277 |
| Chain | Residue | Details |
| A | TYR195 | |
| B | TYR195 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22955277, ECO:0000269|Ref.5 |
| Chain | Residue | Details |
| A | TRP96 | |
| A | ARG130 | |
| A | GLU148 | |
| B | TRP96 | |
| B | ARG130 | |
| B | GLU148 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Lowers pKa of active site Cys => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR253 | |
| A | TYR296 | |
| B | TYR253 | |
| B | TYR296 |
