4G0J

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0016787	molecular_function	hydrolase activity
A	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
A	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
A	0019079	biological_process	viral genome replication
A	0030430	cellular_component	host cell cytoplasm
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0003723	molecular_function	RNA binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0016787	molecular_function	hydrolase activity
B	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
B	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
B	0019079	biological_process	viral genome replication
B	0030430	cellular_component	host cell cytoplasm
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0003723	molecular_function	RNA binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0016787	molecular_function	hydrolase activity
C	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
C	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
C	0019079	biological_process	viral genome replication
C	0030430	cellular_component	host cell cytoplasm
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005524	molecular_function	ATP binding
D	0016787	molecular_function	hydrolase activity
D	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
D	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
D	0019079	biological_process	viral genome replication
D	0030430	cellular_component	host cell cytoplasm
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0003723	molecular_function	RNA binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005524	molecular_function	ATP binding
E	0016787	molecular_function	hydrolase activity
E	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
E	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
E	0019079	biological_process	viral genome replication
E	0030430	cellular_component	host cell cytoplasm
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0003723	molecular_function	RNA binding
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005524	molecular_function	ATP binding
F	0016787	molecular_function	hydrolase activity
F	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
F	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
F	0019079	biological_process	viral genome replication
F	0030430	cellular_component	host cell cytoplasm
F	0046872	molecular_function	metal ion binding
G	0000166	molecular_function	nucleotide binding
G	0003723	molecular_function	RNA binding
G	0004550	molecular_function	nucleoside diphosphate kinase activity
G	0005524	molecular_function	ATP binding
G	0016787	molecular_function	hydrolase activity
G	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
G	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
G	0019079	biological_process	viral genome replication
G	0030430	cellular_component	host cell cytoplasm
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0003723	molecular_function	RNA binding
H	0004550	molecular_function	nucleoside diphosphate kinase activity
H	0005524	molecular_function	ATP binding
H	0016787	molecular_function	hydrolase activity
H	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
H	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
H	0019079	biological_process	viral genome replication
H	0030430	cellular_component	host cell cytoplasm
H	0046872	molecular_function	metal ion binding
I	0000166	molecular_function	nucleotide binding
I	0003723	molecular_function	RNA binding
I	0004550	molecular_function	nucleoside diphosphate kinase activity
I	0005524	molecular_function	ATP binding
I	0016787	molecular_function	hydrolase activity
I	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
I	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
I	0019079	biological_process	viral genome replication
I	0030430	cellular_component	host cell cytoplasm
I	0046872	molecular_function	metal ion binding
J	0000166	molecular_function	nucleotide binding
J	0003723	molecular_function	RNA binding
J	0004550	molecular_function	nucleoside diphosphate kinase activity
J	0005524	molecular_function	ATP binding
J	0016787	molecular_function	hydrolase activity
J	0016817	molecular_function	hydrolase activity, acting on acid anhydrides
J	0017111	molecular_function	ribonucleoside triphosphate phosphatase activity
J	0019079	biological_process	viral genome replication
J	0030430	cellular_component	host cell cytoplasm
J	0046872	molecular_function	metal ion binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Region: {"description":"RNA-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22811529","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"For NTPase and RTPase activities","evidences":[{"source":"HAMAP-Rule","id":"MF_04089","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17804496","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04089","evidenceCode":"ECO:0000255"},{"source":"PDB","id":"2R7P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---