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4G0J

Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5'-GG Sequence for RTPase activity

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003723molecular_functionRNA binding
A0004550molecular_functionnucleoside diphosphate kinase activity
A0005524molecular_functionATP binding
A0016787molecular_functionhydrolase activity
A0016817molecular_functionhydrolase activity, acting on acid anhydrides
A0017111molecular_functionribonucleoside triphosphate phosphatase activity
A0019079biological_processviral genome replication
A0030430cellular_componenthost cell cytoplasm
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0003723molecular_functionRNA binding
B0004550molecular_functionnucleoside diphosphate kinase activity
B0005524molecular_functionATP binding
B0016787molecular_functionhydrolase activity
B0016817molecular_functionhydrolase activity, acting on acid anhydrides
B0017111molecular_functionribonucleoside triphosphate phosphatase activity
B0019079biological_processviral genome replication
B0030430cellular_componenthost cell cytoplasm
B0046872molecular_functionmetal ion binding
C0000166molecular_functionnucleotide binding
C0003723molecular_functionRNA binding
C0004550molecular_functionnucleoside diphosphate kinase activity
C0005524molecular_functionATP binding
C0016787molecular_functionhydrolase activity
C0016817molecular_functionhydrolase activity, acting on acid anhydrides
C0017111molecular_functionribonucleoside triphosphate phosphatase activity
C0019079biological_processviral genome replication
C0030430cellular_componenthost cell cytoplasm
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0003723molecular_functionRNA binding
D0004550molecular_functionnucleoside diphosphate kinase activity
D0005524molecular_functionATP binding
D0016787molecular_functionhydrolase activity
D0016817molecular_functionhydrolase activity, acting on acid anhydrides
D0017111molecular_functionribonucleoside triphosphate phosphatase activity
D0019079biological_processviral genome replication
D0030430cellular_componenthost cell cytoplasm
D0046872molecular_functionmetal ion binding
E0000166molecular_functionnucleotide binding
E0003723molecular_functionRNA binding
E0004550molecular_functionnucleoside diphosphate kinase activity
E0005524molecular_functionATP binding
E0016787molecular_functionhydrolase activity
E0016817molecular_functionhydrolase activity, acting on acid anhydrides
E0017111molecular_functionribonucleoside triphosphate phosphatase activity
E0019079biological_processviral genome replication
E0030430cellular_componenthost cell cytoplasm
E0046872molecular_functionmetal ion binding
F0000166molecular_functionnucleotide binding
F0003723molecular_functionRNA binding
F0004550molecular_functionnucleoside diphosphate kinase activity
F0005524molecular_functionATP binding
F0016787molecular_functionhydrolase activity
F0016817molecular_functionhydrolase activity, acting on acid anhydrides
F0017111molecular_functionribonucleoside triphosphate phosphatase activity
F0019079biological_processviral genome replication
F0030430cellular_componenthost cell cytoplasm
F0046872molecular_functionmetal ion binding
G0000166molecular_functionnucleotide binding
G0003723molecular_functionRNA binding
G0004550molecular_functionnucleoside diphosphate kinase activity
G0005524molecular_functionATP binding
G0016787molecular_functionhydrolase activity
G0016817molecular_functionhydrolase activity, acting on acid anhydrides
G0017111molecular_functionribonucleoside triphosphate phosphatase activity
G0019079biological_processviral genome replication
G0030430cellular_componenthost cell cytoplasm
G0046872molecular_functionmetal ion binding
H0000166molecular_functionnucleotide binding
H0003723molecular_functionRNA binding
H0004550molecular_functionnucleoside diphosphate kinase activity
H0005524molecular_functionATP binding
H0016787molecular_functionhydrolase activity
H0016817molecular_functionhydrolase activity, acting on acid anhydrides
H0017111molecular_functionribonucleoside triphosphate phosphatase activity
H0019079biological_processviral genome replication
H0030430cellular_componenthost cell cytoplasm
H0046872molecular_functionmetal ion binding
I0000166molecular_functionnucleotide binding
I0003723molecular_functionRNA binding
I0004550molecular_functionnucleoside diphosphate kinase activity
I0005524molecular_functionATP binding
I0016787molecular_functionhydrolase activity
I0016817molecular_functionhydrolase activity, acting on acid anhydrides
I0017111molecular_functionribonucleoside triphosphate phosphatase activity
I0019079biological_processviral genome replication
I0030430cellular_componenthost cell cytoplasm
I0046872molecular_functionmetal ion binding
J0000166molecular_functionnucleotide binding
J0003723molecular_functionRNA binding
J0004550molecular_functionnucleoside diphosphate kinase activity
J0005524molecular_functionATP binding
J0016787molecular_functionhydrolase activity
J0016817molecular_functionhydrolase activity, acting on acid anhydrides
J0017111molecular_functionribonucleoside triphosphate phosphatase activity
J0019079biological_processviral genome replication
J0030430cellular_componenthost cell cytoplasm
J0046872molecular_functionmetal ion binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsACT_SITE: For NTPase and RTPase activities => ECO:0000255|HAMAP-Rule:MF_04089, ECO:0000305|PubMed:17804496
ChainResidueDetails
AHIS225
JHIS225
BHIS225
CHIS225
DHIS225
EHIS225
FHIS225
GHIS225
HHIS225
IHIS225

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_04089, ECO:0007744|PDB:2R7P
ChainResidueDetails
ASER107
CLYS188
CHIS221
CARG227
DSER107
DLYS188
DHIS221
DARG227
ESER107
ELYS188
EHIS221
ALYS188
EARG227
FSER107
FLYS188
FHIS221
FARG227
GSER107
GLYS188
GHIS221
GARG227
HSER107
AHIS221
HLYS188
HHIS221
HARG227
ISER107
ILYS188
IHIS221
IARG227
JSER107
JLYS188
JHIS221
AARG227
JARG227
BSER107
BLYS188
BHIS221
BARG227
CSER107

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PDB entries from 2024-07-24

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