4FZ1
Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0015280 | molecular_function | ligand-gated sodium channel activity |
| A | 0016020 | cellular_component | membrane |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0035821 | biological_process | modulation of process of another organism |
| D | 0090729 | molecular_function | toxin activity |
| D | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS01206 |
| Number of Residues | 21 |
| Details | ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC |
| Chain | Residue | Details |
| A | TYR304-CYS324 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | SITE: Key residue for interaction with ASIC1a => ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900, ECO:0000269|PubMed:26248594 |
| Chain | Residue | Details |
| D | TRP7 | |
| D | ARG28 | |
| D | PHE30 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Key residue for interaction with ASIC1a => ECO:0000269|PubMed:21825095, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900 |
| Chain | Residue | Details |
| D | TRP24 | |
| D | ARG26 | |
| D | ARG27 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | TRANSMEM: Discontinuously helical |
| Chain | Residue | Details |
| A | VAL427-PHE453 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for channel gating |
| Chain | Residue | Details |
| A | TYR72 | |
| A | TRP288 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Important for channel desensitizing |
| Chain | Residue | Details |
| A | GLU80 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900 |
| Chain | Residue | Details |
| A | ASN367 | |
| A | ASN394 |
