4FYY
E. coli Aspartate Transcarbamoylase Complexed with CTP, UTP, and Mg2+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
A | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006520 | biological_process | amino acid metabolic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
A | 0016597 | molecular_function | amino acid binding |
A | 0016740 | molecular_function | transferase activity |
A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0070207 | biological_process | protein homotrimerization |
B | 0005515 | molecular_function | protein binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0008270 | molecular_function | zinc ion binding |
B | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
B | 0046872 | molecular_function | metal ion binding |
C | 0004070 | molecular_function | aspartate carbamoyltransferase activity |
C | 0004088 | molecular_function | carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity |
C | 0005515 | molecular_function | protein binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
C | 0006520 | biological_process | amino acid metabolic process |
C | 0006541 | biological_process | glutamine metabolic process |
C | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
C | 0016597 | molecular_function | amino acid binding |
C | 0016740 | molecular_function | transferase activity |
C | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
C | 0070207 | biological_process | protein homotrimerization |
D | 0005515 | molecular_function | protein binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
D | 0008270 | molecular_function | zinc ion binding |
D | 0009347 | cellular_component | aspartate carbamoyltransferase complex |
D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 201 |
Chain | Residue |
B | CYS109 |
B | CYS114 |
B | CYS138 |
B | CYS141 |
site_id | AC2 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UTP B 202 |
Chain | Residue |
B | SER50 |
B | GLY51 |
B | GLU52 |
B | LYS56 |
B | LEU58 |
B | LYS60 |
B | CTP203 |
B | MG204 |
B | HOH301 |
B | HOH302 |
B | HOH313 |
B | LEU7 |
B | GLN8 |
B | VAL9 |
B | HIS20 |
B | PRO49 |
site_id | AC3 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE CTP B 203 |
Chain | Residue |
B | ALA11 |
B | ILE12 |
B | VAL17 |
B | ASP19 |
B | HIS20 |
B | LYS60 |
B | ASN84 |
B | ILE86 |
B | TYR89 |
B | VAL91 |
B | LYS94 |
B | ASN132 |
B | UTP202 |
B | MG204 |
B | HOH301 |
B | HOH302 |
B | HOH304 |
B | HOH333 |
B | HOH358 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG B 204 |
Chain | Residue |
B | UTP202 |
B | CTP203 |
B | HOH301 |
B | HOH302 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 201 |
Chain | Residue |
D | CYS109 |
D | CYS114 |
D | CYS138 |
D | CYS141 |
site_id | AC6 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UTP D 202 |
Chain | Residue |
D | LYS6 |
D | LEU7 |
D | GLN8 |
D | VAL9 |
D | HIS20 |
D | PRO49 |
D | SER50 |
D | GLY51 |
D | GLU52 |
D | LYS56 |
D | LYS60 |
D | CTP203 |
D | MG204 |
D | HOH317 |
D | HOH385 |
D | HOH391 |
site_id | AC7 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE CTP D 203 |
Chain | Residue |
D | ALA11 |
D | ILE12 |
D | VAL17 |
D | ASP19 |
D | HIS20 |
D | LYS60 |
D | ASN84 |
D | TYR89 |
D | VAL91 |
D | LYS94 |
D | UTP202 |
D | MG204 |
D | HOH305 |
D | HOH317 |
D | HOH330 |
D | HOH344 |
D | HOH385 |
D | HOH386 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MG D 204 |
Chain | Residue |
D | UTP202 |
D | CTP203 |
D | HOH317 |
D | HOH385 |
Functional Information from PROSITE/UniProt
site_id | PS00097 |
Number of Residues | 8 |
Details | CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT |
Chain | Residue | Details |
A | PHE48-THR55 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: |
Chain | Residue | Details |
B | CYS109 | |
C | ARG105 | |
C | HIS134 | |
C | GLN137 | |
C | LEU267 | |
C | PRO268 | |
B | CYS114 | |
B | CYS138 | |
B | CYS141 | |
D | CYS109 | |
D | CYS114 | |
D | CYS138 | |
D | CYS141 | |
C | THR55 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787 |
Chain | Residue | Details |
A | LYS84 | |
A | ARG167 | |
A | ARG229 | |
C | LYS84 | |
C | ARG167 | |
C | ARG229 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 405 |
Chain | Residue | Details |
A | ARG54 | electrostatic stabiliser |
A | THR55 | electrostatic stabiliser, increase electrophilicity |
A | LYS84 | proton shuttle (general acid/base) |
A | ARG105 | electrostatic stabiliser, increase electrophilicity |
A | HIS134 | electrostatic stabiliser, increase electrophilicity |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 405 |
Chain | Residue | Details |
C | ARG54 | electrostatic stabiliser |
C | THR55 | electrostatic stabiliser, increase electrophilicity |
C | LYS84 | proton shuttle (general acid/base) |
C | ARG105 | electrostatic stabiliser, increase electrophilicity |
C | HIS134 | electrostatic stabiliser, increase electrophilicity |