4FYM
Crystal structure of Plasmodium falciparum orotate phosphoribosyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| B | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| C | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| D | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| E | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| E | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| E | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| F | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| F | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| F | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| G | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| G | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016757 | molecular_function | glycosyltransferase activity |
| G | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| G | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| H | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| H | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0016757 | molecular_function | glycosyltransferase activity |
| H | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| H | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | GLU34 |
| A | LEU35 |
| A | VAL36 |
| A | SER59 |
| D | HIS21 |
| D | TYR63 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | THR215 |
| A | ALA216 |
| A | HOH425 |
| A | THR212 |
| A | CYS213 |
| A | GLY214 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | LYS23 |
| A | HIS146 |
| A | PHE147 |
| A | GLU150 |
| B | HIS146 |
| B | SO4304 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 304 |
| Chain | Residue |
| A | CYS11 |
| A | ASP12 |
| A | GLU13 |
| A | LYS77 |
| A | HOH427 |
| B | HOH433 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | PHE211 |
| B | THR212 |
| B | CYS213 |
| B | GLY214 |
| B | THR215 |
| B | ALA216 |
| B | HOH461 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | GLU34 |
| B | LEU35 |
| B | VAL36 |
| B | SER59 |
| F | HIS21 |
| F | TYR63 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| A | HOH456 |
| B | CYS11 |
| B | ASP12 |
| B | GLU13 |
| B | LYS77 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 304 |
| Chain | Residue |
| A | HIS146 |
| A | SO4303 |
| B | LYS23 |
| B | HIS146 |
| B | PHE147 |
| B | GLU150 |
| B | HOH438 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 305 |
| Chain | Residue |
| A | ARG163 |
| B | SER134 |
| B | TYR135 |
| B | LYS136 |
| B | HOH441 |
| B | HOH454 |
| B | HOH462 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 301 |
| Chain | Residue |
| C | SER134 |
| C | TYR135 |
| C | LYS136 |
| C | LYS164 |
| C | HOH434 |
| D | ARG163 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 302 |
| Chain | Residue |
| C | THR212 |
| C | CYS213 |
| C | GLY214 |
| C | THR215 |
| C | ALA216 |
| C | HOH403 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 303 |
| Chain | Residue |
| C | CYS11 |
| C | ASP12 |
| C | LYS77 |
| C | HOH429 |
| D | HOH443 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 304 |
| Chain | Residue |
| C | HIS21 |
| C | LYS25 |
| C | TYR63 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 305 |
| Chain | Residue |
| C | LYS23 |
| C | HIS146 |
| C | PHE147 |
| C | GLU150 |
| D | HIS146 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| C | HOH418 |
| D | CYS11 |
| D | ASP12 |
| D | LYS77 |
| D | HOH406 |
| D | HOH428 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| C | HIS146 |
| D | LYS23 |
| D | HIS146 |
| D | PHE147 |
| D | GLU150 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| D | THR212 |
| D | CYS213 |
| D | GLY214 |
| D | THR215 |
| D | ALA216 |
| D | HOH427 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 304 |
| Chain | Residue |
| D | SER134 |
| D | TYR135 |
| D | LYS136 |
| D | LYS164 |
| C | ARG163 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 305 |
| Chain | Residue |
| A | HIS21 |
| A | TYR63 |
| D | GLU34 |
| D | LEU35 |
| D | VAL36 |
| D | HOH440 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 301 |
| Chain | Residue |
| E | SER134 |
| E | TYR135 |
| E | LYS136 |
| E | LYS164 |
| H | ARG163 |
| H | LYS167 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 302 |
| Chain | Residue |
| E | HIS21 |
| E | LYS25 |
| E | TYR63 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 303 |
| Chain | Residue |
| E | THR212 |
| E | CYS213 |
| E | GLY214 |
| E | THR215 |
| E | ALA216 |
| E | HOH403 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 E 304 |
| Chain | Residue |
| E | LYS23 |
| E | HIS146 |
| E | PHE147 |
| E | GLU150 |
| H | HIS146 |
| H | GLU150 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 F 301 |
| Chain | Residue |
| F | ASP12 |
| F | LYS77 |
| F | HOH404 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 302 |
| Chain | Residue |
| B | HIS21 |
| B | TYR63 |
| F | GLU34 |
| F | LEU35 |
| F | VAL36 |
| F | SER59 |
| F | HOH401 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 303 |
| Chain | Residue |
| F | THR212 |
| F | CYS213 |
| F | GLY214 |
| F | THR215 |
| F | ALA216 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 F 304 |
| Chain | Residue |
| F | LYS23 |
| F | HIS146 |
| F | PHE147 |
| F | GLU150 |
| G | HIS146 |
| G | SO4301 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 G 301 |
| Chain | Residue |
| F | HIS146 |
| F | SO4304 |
| G | LYS23 |
| G | HIS146 |
| G | PHE147 |
| G | GLU150 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 302 |
| Chain | Residue |
| G | THR212 |
| G | CYS213 |
| G | GLY214 |
| G | THR215 |
| G | ALA216 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 303 |
| Chain | Residue |
| G | CYS11 |
| G | ASP12 |
| G | LYS77 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 H 301 |
| Chain | Residue |
| E | ARG163 |
| H | SER134 |
| H | TYR135 |
| H | LYS136 |
| H | LYS164 |
| site_id | DC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 302 |
| Chain | Residue |
| E | HIS146 |
| E | GLU150 |
| H | LYS23 |
| H | HIS146 |
| H | PHE147 |
| H | GLU150 |
| site_id | DC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 H 303 |
| Chain | Residue |
| H | PHE211 |
| H | THR212 |
| H | CYS213 |
| H | GLY214 |
| H | THR215 |
| H | ALA216 |
