Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4FXE

Crystal structure of the intact E. coli RelBE toxin-antitoxin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032993	cellular_component	protein-DNA complex
A	0040008	biological_process	regulation of growth
A	0043565	molecular_function	sequence-specific DNA binding
A	0044010	biological_process	single-species biofilm formation
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0097351	molecular_function	toxin sequestering activity
A	0110001	cellular_component	toxin-antitoxin complex
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0032993	cellular_component	protein-DNA complex
B	0040008	biological_process	regulation of growth
B	0043565	molecular_function	sequence-specific DNA binding
B	0044010	biological_process	single-species biofilm formation
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0097351	molecular_function	toxin sequestering activity
B	0110001	cellular_component	toxin-antitoxin complex
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0032993	cellular_component	protein-DNA complex
C	0040008	biological_process	regulation of growth
C	0043565	molecular_function	sequence-specific DNA binding
C	0044010	biological_process	single-species biofilm formation
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0097351	molecular_function	toxin sequestering activity
C	0110001	cellular_component	toxin-antitoxin complex
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0004521	molecular_function	RNA endonuclease activity
D	0005515	molecular_function	protein binding
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006402	biological_process	mRNA catabolic process
D	0016787	molecular_function	hydrolase activity
D	0017148	biological_process	negative regulation of translation
D	0019843	molecular_function	rRNA binding
D	0032993	cellular_component	protein-DNA complex
D	0034198	biological_process	cellular response to amino acid starvation
D	0040008	biological_process	regulation of growth
D	0043022	molecular_function	ribosome binding
D	0044010	biological_process	single-species biofilm formation
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046677	biological_process	response to antibiotic
D	0097351	molecular_function	toxin sequestering activity
D	0110001	cellular_component	toxin-antitoxin complex
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001217	molecular_function	DNA-binding transcription repressor activity
E	0003723	molecular_function	RNA binding
E	0004518	molecular_function	nuclease activity
E	0004519	molecular_function	endonuclease activity
E	0004521	molecular_function	RNA endonuclease activity
E	0005515	molecular_function	protein binding
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006402	biological_process	mRNA catabolic process
E	0016787	molecular_function	hydrolase activity
E	0017148	biological_process	negative regulation of translation
E	0019843	molecular_function	rRNA binding
E	0032993	cellular_component	protein-DNA complex
E	0034198	biological_process	cellular response to amino acid starvation
E	0040008	biological_process	regulation of growth
E	0043022	molecular_function	ribosome binding
E	0044010	biological_process	single-species biofilm formation
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046677	biological_process	response to antibiotic
E	0097351	molecular_function	toxin sequestering activity
E	0110001	cellular_component	toxin-antitoxin complex
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001217	molecular_function	DNA-binding transcription repressor activity
F	0003723	molecular_function	RNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004521	molecular_function	RNA endonuclease activity
F	0005515	molecular_function	protein binding
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006402	biological_process	mRNA catabolic process
F	0016787	molecular_function	hydrolase activity
F	0017148	biological_process	negative regulation of translation
F	0019843	molecular_function	rRNA binding
F	0032993	cellular_component	protein-DNA complex
F	0034198	biological_process	cellular response to amino acid starvation
F	0040008	biological_process	regulation of growth
F	0043022	molecular_function	ribosome binding
F	0044010	biological_process	single-species biofilm formation
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0046677	biological_process	response to antibiotic
F	0097351	molecular_function	toxin sequestering activity
F	0110001	cellular_component	toxin-antitoxin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 101

Chain	Residue
A	ARG43
A	LYS47
A	GLN48
A	SO4102

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 102

Chain	Residue
F	ASP68
A	TYR37
A	ARG43
A	PRO45
A	SO4101
B	LYS47

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 101

Chain	Residue
B	ARG43
B	LYS47
B	GLN48

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"24251350","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	5
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"24251350","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"24251350","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)