4FX9
Structure of the Pyrococcus horikoshii CoA persulfide/polysulfide reductase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050451 | molecular_function | CoA-disulfide reductase (NADPH) activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0003756 | molecular_function | protein disulfide isomerase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050451 | molecular_function | CoA-disulfide reductase (NADPH) activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE FAD A 901 |
| Chain | Residue |
| A | GLY13 |
| A | CYS48 |
| A | ALA83 |
| A | GLU84 |
| A | VAL85 |
| A | ASN113 |
| A | GLY114 |
| A | ASP134 |
| A | LEU135 |
| A | TYR161 |
| A | LEU251 |
| A | GLY15 |
| A | GLY282 |
| A | ASP283 |
| A | PRO299 |
| A | LEU300 |
| A | ALA301 |
| A | PRO302 |
| A | COA902 |
| B | TYR425 |
| B | ALA426 |
| B | PRO427 |
| A | ALA16 |
| A | ALA17 |
| A | PHE37 |
| A | GLU38 |
| A | ALA39 |
| A | HIS45 |
| A | PRO47 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE COA A 902 |
| Chain | Residue |
| A | ALA16 |
| A | SER20 |
| A | ARG27 |
| A | SER44 |
| A | HIS45 |
| A | ALA46 |
| A | PRO47 |
| A | CYS48 |
| A | TYR65 |
| A | TYR66 |
| A | ARG75 |
| A | ALA301 |
| A | ASN305 |
| A | FAD901 |
| A | HOH1002 |
| A | HOH1004 |
| B | ILE360 |
| B | LYS361 |
| B | VAL432 |
| B | TRP433 |
| B | VAL438 |
| B | ARG441 |
| B | VAL442 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 901 |
| Chain | Residue |
| A | TYR425 |
| A | ALA426 |
| A | PRO427 |
| B | ILE12 |
| B | GLY13 |
| B | GLY15 |
| B | ALA16 |
| B | ALA17 |
| B | PHE37 |
| B | GLU38 |
| B | ALA39 |
| B | HIS45 |
| B | PRO47 |
| B | CYS48 |
| B | ALA83 |
| B | GLU84 |
| B | VAL85 |
| B | ALA112 |
| B | ASN113 |
| B | GLY114 |
| B | ALA133 |
| B | ASP134 |
| B | LEU135 |
| B | TYR161 |
| B | GLY282 |
| B | ASP283 |
| B | PRO299 |
| B | LEU300 |
| B | ALA301 |
| B | PRO302 |
| B | COA902 |
| B | HOH1003 |
| B | HOH1006 |
| B | HOH1007 |
| B | HOH1008 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE COA B 902 |
| Chain | Residue |
| B | SER44 |
| B | HIS45 |
| B | CYS48 |
| B | TYR65 |
| B | TYR66 |
| B | ARG75 |
| B | ASN305 |
| B | FAD901 |
| B | HOH1001 |
| B | HOH1006 |
| A | ILE360 |
| A | LYS361 |
| A | TYR425 |
| A | VAL432 |
| A | TRP433 |
| A | VAL438 |
| A | ARG441 |
| A | VAL442 |
| B | ALA16 |
| B | MET19 |
| B | SER20 |
| B | ARG27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Redox-active","evidences":[{"source":"PubMed","id":"23530771","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23530771","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29988575","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FX9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23530771","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FX9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
