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4FX8

Crystal structure of the mutant Q185A.R203A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
A0005829cellular_componentcytosol
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0016829molecular_functionlyase activity
A0016831molecular_functioncarboxy-lyase activity
A0044205biological_process'de novo' UMP biosynthetic process
B0004590molecular_functionorotidine-5'-phosphate decarboxylase activity
B0005829cellular_componentcytosol
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0016829molecular_functionlyase activity
B0016831molecular_functioncarboxy-lyase activity
B0044205biological_process'de novo' UMP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE BMP A 301
ChainResidue
AASP20
AHOH408
AHOH420
AHOH428
AHOH431
AHOH440
AHOH446
AHOH447
AHOH449
AHOH465
BASP75
ALYS42
BILE76
BTHR79
AASP70
ALYS72
AMET126
ASER127
APRO180
AGLY202
AALA203

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 302
ChainResidue
AARG14
AARG168
ALEU193
AARG194
APHE195
AALA196
AASP197
AHOH492

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE BMP B 301
ChainResidue
AASP75
AILE76
ATHR79
BASP20
BLYS42
BASP70
BLYS72
BMET126
BSER127
BPRO180
BGLY202
BALA203
BHOH408
BHOH409
BHOH418
BHOH428
BHOH432
BHOH470

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 302
ChainResidue
BARG24
BLEU28
BARG62

Functional Information from PROSITE/UniProt
site_idPS00156
Number of Residues14
DetailsOMPDECASE Orotidine 5'-phosphate decarboxylase active site. IIaDfKvaDIPeTN
ChainResidueDetails
AILE67-ASN80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton donor"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues38
DetailsBinding site: {}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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