4FW4
Crystal Structure of the LpxC in complex with N-[(1S,2R)-2-HYDROXY-1-(HYDROXYCARBAMOYL)PROPYL]-4-(4-PHENYLBUTA-1,3-DIYN-1-YL)BENZAMIDE inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006796 | biological_process | phosphate-containing compound metabolic process |
A | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
A | 0009245 | biological_process | lipid A biosynthetic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019637 | biological_process | organophosphate metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
A | 1901135 | biological_process | carbohydrate derivative metabolic process |
B | 0006796 | biological_process | phosphate-containing compound metabolic process |
B | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
B | 0009245 | biological_process | lipid A biosynthetic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0019637 | biological_process | organophosphate metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
B | 1901135 | biological_process | carbohydrate derivative metabolic process |
C | 0006796 | biological_process | phosphate-containing compound metabolic process |
C | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
C | 0009245 | biological_process | lipid A biosynthetic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0019637 | biological_process | organophosphate metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
C | 1901135 | biological_process | carbohydrate derivative metabolic process |
D | 0006796 | biological_process | phosphate-containing compound metabolic process |
D | 0008759 | molecular_function | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity |
D | 0009245 | biological_process | lipid A biosynthetic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0019637 | biological_process | organophosphate metabolic process |
D | 0046872 | molecular_function | metal ion binding |
D | 0103117 | molecular_function | UDP-3-O-acyl-N-acetylglucosamine deacetylase activity |
D | 1901135 | biological_process | carbohydrate derivative metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 300 |
Chain | Residue |
A | HIS78 |
A | HIS237 |
A | ASP241 |
A | 3P3301 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 3P3 A 301 |
Chain | Residue |
A | ILE197 |
A | GLY209 |
A | SER210 |
A | HIS237 |
A | LYS238 |
A | ASP241 |
A | HIS264 |
A | ZN300 |
A | HOH448 |
A | MET62 |
A | GLU77 |
A | HIS78 |
A | THR190 |
A | PHE191 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 301 |
Chain | Residue |
B | HIS78 |
B | HIS237 |
B | ASP241 |
B | 3P3302 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 3P3 B 302 |
Chain | Residue |
B | MET62 |
B | GLU77 |
B | HIS78 |
B | THR190 |
B | PHE191 |
B | ILE197 |
B | GLY209 |
B | SER210 |
B | HIS237 |
B | LYS238 |
B | ASP241 |
B | HIS264 |
B | ZN301 |
B | HOH454 |
site_id | AC5 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL B 303 |
Chain | Residue |
B | ALA84 |
B | PHE152 |
B | ILE243 |
B | LEU246 |
B | TYR247 |
B | SER252 |
B | LEU253 |
B | HOH409 |
B | HOH499 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 301 |
Chain | Residue |
C | HIS78 |
C | HIS237 |
C | ASP241 |
C | 3P3302 |
site_id | AC7 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 3P3 C 302 |
Chain | Residue |
C | MET62 |
C | GLU77 |
C | HIS78 |
C | THR190 |
C | PHE191 |
C | ILE197 |
C | ARG201 |
C | GLY209 |
C | SER210 |
C | HIS237 |
C | ASP241 |
C | HIS264 |
C | ZN301 |
C | HOH450 |
site_id | AC8 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL C 303 |
Chain | Residue |
C | ALA84 |
C | PHE152 |
C | ILE243 |
C | LEU246 |
C | TYR247 |
C | SER252 |
C | LEU253 |
C | TYR296 |
C | HOH408 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT C 304 |
Chain | Residue |
C | LYS29 |
C | SER40 |
C | GLU49 |
C | GLU94 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 301 |
Chain | Residue |
D | HIS78 |
D | HIS237 |
D | ASP241 |
D | 3P3302 |
site_id | BC2 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 3P3 D 302 |
Chain | Residue |
D | MET62 |
D | GLU77 |
D | HIS78 |
D | THR190 |
D | PHE191 |
D | ILE197 |
D | ARG201 |
D | GLY209 |
D | SER210 |
D | HIS237 |
D | ASP241 |
D | HIS264 |
D | ZN301 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL D 303 |
Chain | Residue |
D | HOH461 |
D | HOH465 |
D | PHE152 |
D | ILE243 |
D | LEU246 |
D | TYR247 |
D | SER252 |
D | LEU253 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00388 |
Chain | Residue | Details |
A | HIS264 | |
B | HIS264 | |
C | HIS264 | |
D | HIS264 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00388 |
Chain | Residue | Details |
C | ASP241 | |
D | HIS78 | |
D | HIS237 | |
D | ASP241 | |
A | HIS78 | |
A | HIS237 | |
A | ASP241 | |
B | HIS78 | |
B | HIS237 | |
B | ASP241 | |
C | HIS78 | |
C | HIS237 |