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4FVX

Structure of rat nNOS heme domain in complex with N(omega)-ethoxy-L-arginine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0006809biological_processnitric oxide biosynthetic process
B0004517molecular_functionnitric-oxide synthase activity
B0006809biological_processnitric oxide biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE HEM A 801
ChainResidue
ATRP409
APHE704
ATYR706
AH4B802
A2KJ803
ATFA804
AHOH904
AHOH914
AHOH1017
AHOH1057
ACYS415
AVAL416
ASER457
APHE584
ASER585
ATRP587
AGLU592
ATRP678

site_idAC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE H4B A 802
ChainResidue
ASER334
AARG596
AVAL677
ATRP678
AHEM801
AHOH901
AHOH914
AHOH926
AHOH969
AHOH1061
BTRP676
BPHE691
BHIS692

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 2KJ A 803
ChainResidue
AGLN478
ATYR562
APRO565
AVAL567
APHE584
AGLY586
ATRP587
ATYR588
AGLU592
AASP597
AHEM801
AHOH924

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE TFA A 804
ChainResidue
AGLY417
AILE419
ATRP587
AVAL649
AALA654
ASER657
AHEM801
AHOH1000

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 805
ChainResidue
ACYS326
ACYS331
BCYS326
BCYS331

site_idAC6
Number of Residues17
DetailsBINDING SITE FOR RESIDUE HEM B 801
ChainResidue
BTRP409
BCYS415
BSER457
BPHE584
BSER585
BTRP587
BGLU592
BPHE704
BTYR706
BH4B802
B2KJ803
BTFA804
BHOH906
BHOH935
BHOH958
BHOH1039
BHOH1087

site_idAC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE H4B B 802
ChainResidue
ATRP676
APHE691
AHIS692
AGLN693
AGLU694
BSER334
BARG596
BVAL677
BTRP678
BHEM801
BHOH903
BHOH935
BHOH965
BHOH982
BHOH1065

site_idAC8
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 2KJ B 803
ChainResidue
BGLN478
BTYR562
BPRO565
BVAL567
BPHE584
BGLY586
BTRP587
BTYR588
BGLU592
BASP597
BHEM801
BHOH925

site_idAC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE TFA B 804
ChainResidue
BGLY417
BILE419
BGLN420
BTRP587
BHEM801
BHOH1125

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCVGRIqW
ChainResidueDetails
AARG414-TRP421

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P29475
ChainResidueDetails
ASER334
BSER334
BGLN478
BTRP587
BTYR588
BGLU592
BVAL677
BTRP678
BPHE691
BTYR706
AGLN478
ATRP587
ATYR588
AGLU592
AVAL677
ATRP678
APHE691
ATYR706

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: axial binding residue => ECO:0000250|UniProtKB:P29475
ChainResidueDetails
ACYS415
BCYS415

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PDB entries from 2024-11-06

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