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4FVR

Crystal structure of the Jak2 pseudokinase domain mutant V617F (Mg-ATP-bound form)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE ATP A 901
ChainResidue
ALEU551
AVAL629
ASER633
AASN673
ALYS677
AASN678
ALEU680
AMG902
AHOH1012
AHOH1032
AHOH1058
AGLY554
AHOH1099
AHOH1100
AHOH1103
AHOH1104
ATHR555
ATHR557
AILE559
ALEU579
ALYS581
AGLN626
AGLU627

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 902
ChainResidue
AASN678
AATP901
AHOH1103
AHOH1104

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Breakpoint for translocation to form PCM1-JAK2 fusion protein
ChainResidueDetails
AASP710

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATYR570

222926

PDB entries from 2024-07-24

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