4FVA

Crystal structure of truncated Caenorhabditis elegans TDP2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 401

Chain	Residue
A	PHE205
A	GLN206

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	ASP128
A	GLU158
A	LYS311
A	MLI403
A	HOH501
A	HOH520
A	HOH554

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLI A 403

Chain	Residue
A	ASN126
A	GLU158
A	HIS232
A	SER235
A	ASN273
A	MG402
A	HOH509
A	HOH619
A	HOH632

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 404

Chain	Residue
A	ASN150
A	LEU173
A	SER192
A	HOH533
A	HOH538

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 405

Chain	Residue
A	ARG237
A	ARG275
C	ARG344

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 406

Chain	Residue
A	ASP114

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 401

Chain	Residue
B	HIS204
B	PHE205
B	GLN206

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 402

Chain	Residue
D	GLU113
D	ASP114
D	LEU115

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	ASP128
B	GLU158
B	MLI404
B	HOH505
B	HOH537
B	HOH614

---

site_id	BC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MLI B 404

Chain	Residue
B	ASN126
B	GLU158
B	HIS232
B	SER235
B	ASP271
B	ASN273
B	MG403
B	HOH512
B	HOH517
B	HOH614

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 405

Chain	Residue
B	GLY285
B	TRP326
B	SER327
B	GLY328
B	LEU330
B	HOH647

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MLI B 406

Chain	Residue
B	ASN150
B	PRO151
B	ASP152
B	SER192
B	HOH538
B	HOH635
B	HOH637
B	HOH638

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 407

Chain	Residue
B	PHE314
B	HOH601

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 408

Chain	Residue
B	GLN341
B	ARG342
B	HOH557
C	LEU130
C	ASP131
C	GLY132

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 409

Chain	Residue
B	HIS144

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 401

Chain	Residue
C	ASP128
C	GLU158
C	MLI402
C	HOH506
C	HOH546
C	HOH647

---

site_id	BC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MLI C 402

Chain	Residue
C	ASN126
C	GLU158
C	HIS232
C	SER235
C	ASN273
C	MG401
C	HOH521
C	HOH528
C	HOH647

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO C 403

Chain	Residue
C	PHE205
C	GLN206

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 404

Chain	Residue
A	LYS181
C	PHE118
C	GLU119

---

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 405

Chain	Residue
A	ASP168
A	HOH546
C	GLU119
C	ASP152
C	HOH569
C	HOH646

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 406

Chain	Residue
C	PRO151
C	ASP152
C	LEU173
C	HOH501
C	HOH543
C	ASN150

---

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 401

Chain	Residue
D	ASP128
D	GLU158
D	MLI402
D	HOH529
D	HOH589
D	HOH617

---

site_id	CC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE MLI D 402

Chain	Residue
D	ASN126
D	GLU158
D	HIS232
D	SER235
D	ASP271
D	ASN273
D	MG401
D	EDO404
D	HOH514
D	HOH515
D	HOH589
D	HOH626

---

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 403

Chain	Residue
D	PHE205
D	GLN206
D	HOH556

---

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 404

Chain	Residue
D	THR236
D	ASN273
D	ARG275
D	PHE321
D	MLI402
D	HOH626

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 405

Chain	Residue
D	SER121
D	VAL149
D	ASN150
D	ASP152
D	HOH588

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	44
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"O95551","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104058","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FVA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"UniProtKB","id":"Q9JJX7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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