4FUC

Crystal Structure of the Urokinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 239 A 301

Chain	Residue
A	HIS46
A	GLY229
A	SIN302
A	HOH427
A	ASP50
A	HIS94
A	ASP192
A	SER193
A	GLN195
A	SER198
A	TRP218
A	GLY221

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SIN A 302

Chain	Residue
A	VAL30
A	CYS31
A	HIS46
A	CYS47
A	GLN195
A	GLY196
A	SER198
A	239301
A	HOH706
A	HOH712

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 303

Chain	Residue
A	LYS180
A	HIS236
A	HOH494
A	HOH641
A	HOH723
A	HOH751

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 304

Chain	Residue
A	ARG23
A	LYS53
A	HIS95
A	THR178
A	LYS180
A	MET181
A	HOH420
A	HOH501
A	HOH709

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 305

Chain	Residue
A	TYR126
A	ARG233
A	HIS236
A	HOH505
A	HOH506
A	HOH507

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 306

Chain	Residue
A	ARG21
A	ARG23
A	GLY24
A	HOH765

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 307

Chain	Residue
A	THR178
A	THR179
A	HOH501
A	HOH502
A	HOH538
A	HOH657
A	HOH709

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 308

Chain	Residue
A	THR28
A	TYR29
A	TYR150
A	GOL311
A	HOH414
A	HOH438
A	HOH580

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 309

Chain	Residue
A	PRO52
A	LEU81
A	ASP90
A	THR91
A	GLU176
A	HOH482
A	HOH492
A	HOH508

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 310

Chain	Residue
A	ARG20
A	HIS22
A	ARG23
A	TYR51
A	HOH573

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 311

Chain	Residue
A	THR28
A	TYR29
A	ASN67
A	GOL308
A	GOL314
A	HOH583
A	HOH747

---

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 312

Chain	Residue
A	SER37
A	PRO38
A	CYS39
A	TRP40
A	LEU206
A	GLN207
A	HOH512
A	HOH607
A	HOH752

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 313

Chain	Residue
A	GLU5
A	ASN11
A	LYS142
A	MET156
A	GLN195
A	HOH535
A	HOH566

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 314

Chain	Residue
A	ARG63
A	ASN67
A	GOL311
A	HOH651
A	HOH652
A	VAL27
A	TYR60

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 315

Chain	Residue
A	LYS75
A	LYS106
A	LYS225
A	HOH490
A	HOH591
A	HOH594

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
A	ILE42-CYS47

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP192-VAL203

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	245
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9151681","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000026"}

Chain

Residue

Details

---