4FUA

L-FUCULOSE-1-PHOSPHATE ALDOLASE COMPLEX WITH PGH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0005996	biological_process	monosaccharide metabolic process
A	0006004	biological_process	fucose metabolic process
A	0008270	molecular_function	zinc ion binding
A	0008738	molecular_function	L-fuculose-phosphate aldolase activity
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0019317	biological_process	fucose catabolic process
A	0019323	biological_process	pentose catabolic process
A	0019568	biological_process	arabinose catabolic process
A	0019571	biological_process	D-arabinose catabolic process
A	0042355	biological_process	L-fucose catabolic process
A	0046872	molecular_function	metal ion binding
A	0046914	molecular_function	transition metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 216

Chain	Residue
A	HIS92
A	HIS94
A	TYR113
A	HIS155
A	PGH217

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 300

Chain	Residue
A	ASN146
A	ARG147
A	ARG147

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 301

Chain	Residue
A	CYS14
A	ILE45
A	HOH460

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PGH A 217

Chain	Residue
A	THR26
A	GLY28
A	ASN29
A	THR43
A	GLY44
A	SER71
A	SER72
A	GLU73
A	HIS92
A	HIS94
A	TYR113
A	HIS155
A	ZN216
A	HOH431

---

site_id	ACT
Number of Residues	6
Details	THE ACTIVE CENTER IS DEFINED BY THE ZINC ION, THE FOUR ZINC COORDINATING RESIDUES AND TYR-1 13 FROM THE ADJACENT SUBUNIT.

Chain	Residue
A	ZN216
A	GLU73
A	HIS92
A	HIS94
A	HIS155
A	TYR113

---

site_id	PBS
Number of Residues	5
Details	BINDING SITE FOR THE SUBSTRATE PHOSPHATE GROUP.

Chain	Residue
A	THR43
A	GLY44
A	SER71
A	SER72
A	ASN29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00987","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299567","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00987","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11054289","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15299567","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8676381","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DZU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E48","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E49","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1E4C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4FUA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Plays a key role in the stabilization of the transition state and positioning the aldehyde component","evidences":[{"source":"PubMed","id":"10821675","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1fua

Chain	Residue	Details
A	TYR113
A	GLU73

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fua

Chain	Residue	Details
A	ALA117

---

site_id	MCSA1
Number of Residues	5
Details	M-CSA 72

Chain	Residue	Details
A	GLU73	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	HIS92	metal ligand
A	HIS94	metal ligand
A	TYR113	electrostatic stabiliser, transition state stabiliser
A	HIS155	metal ligand

---