4FT4
crystal structure of Zea mays ZMET2 in complex H3(1-32)K9me2 peptide and SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| B | 0003682 | molecular_function | chromatin binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| P | 0000786 | cellular_component | nucleosome |
| P | 0003677 | molecular_function | DNA binding |
| P | 0030527 | molecular_function | structural constituent of chromatin |
| P | 0046982 | molecular_function | protein heterodimerization activity |
| Q | 0000786 | cellular_component | nucleosome |
| Q | 0003677 | molecular_function | DNA binding |
| Q | 0030527 | molecular_function | structural constituent of chromatin |
| Q | 0046982 | molecular_function | protein heterodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAH B 1000 |
| Chain | Residue |
| A | HOH1125 |
| B | GLU396 |
| B | LYS397 |
| B | ALA398 |
| B | PRO516 |
| B | ASN851 |
| B | ALA852 |
| B | VAL853 |
| B | HOH1162 |
| B | HOH1209 |
| B | TYR347 |
| B | SER348 |
| B | GLY349 |
| B | GLY351 |
| B | GLY352 |
| B | MET353 |
| B | ASP375 |
| B | PHE376 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SAH A 1000 |
| Chain | Residue |
| A | TYR347 |
| A | GLY349 |
| A | GLY351 |
| A | GLY352 |
| A | MET353 |
| A | ASP375 |
| A | PHE376 |
| A | ASN377 |
| A | GLU396 |
| A | LYS397 |
| A | ALA398 |
| A | GLN540 |
| A | ASN851 |
| A | ALA852 |
| A | VAL853 |
| A | HOH1114 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15983376, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | GLN5 | |
| Q | GLN5 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine => ECO:0000269|PubMed:15983376 |
| Chain | Residue | Details |
| P | THR6 | |
| Q | THR6 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:14610360, ECO:0000269|PubMed:15753571 |
| Chain | Residue | Details |
| P | SER10 | |
| Q | SER10 | |
| P | SER28 | |
| Q | SER28 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| P | ALA25 | |
| Q | ALA25 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:20850016 |
| Chain | Residue | Details |
| P | ARG26 | |
| Q | ARG26 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | SITE: Not N6-methylated => ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| P | LYS14 | |
| Q | LYS14 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | SITE: Not N6-acetylated => ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| P | LYS27 | |
| Q | LYS27 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Required for interaction with TSK => ECO:0000269|PubMed:35298257 |
| Chain | Residue | Details |
| P | ALA31 | |
| Q | ALA31 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12581305, ECO:0000269|PubMed:14712277, ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:16258034 |
| Chain | Residue | Details |
| P | LYS4 | |
| Q | LYS4 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12456661, ECO:0000269|PubMed:12581305, ECO:0000269|PubMed:14712277, ECO:0000269|PubMed:15014946, ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| P | MLY9 | |
| Q | MLY9 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:15753571 |
| Chain | Residue | Details |
| P | THR11 | |
| Q | THR11 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:16648464, ECO:0000269|PubMed:17174094, ECO:0000269|PubMed:17363895 |
| Chain | Residue | Details |
| P | LYS14 | |
| Q | LYS14 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:15598823 |
| Chain | Residue | Details |
| P | LYS18 | |
| P | LYS23 | |
| Q | LYS18 | |
| Q | LYS23 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:14712277, ECO:0000269|PubMed:15598823, ECO:0000269|PubMed:17174094, ECO:0000269|PubMed:17439305, ECO:0000269|PubMed:19503079, ECO:0000269|PubMed:24626927, ECO:0000269|PubMed:35298257 |
| Chain | Residue | Details |
| P | LYS27 | |
| Q | LYS27 |
